Publications

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MRC Toxicology Unit Publications 2016

 

 

Anne Willis’s group:

 

Published in the European Journal of Medicinal Chemistry on 29 November 2016 (Epub ahead of print): ‘Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.’ Soukarieh F, Nowicki MW, Bastide A, Pöyry T, Jones C, Dudek K, Patwardhan G, Meullenet F, Oldham NJ, Walkinshaw MD, Willis AE, Fischer PM.

 

Published in Oncotarget on 27 August 2016 (Epub ahead of print): ‘PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2? phosphorylation in established cell lines and primary human leukemia cells.’ Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Sanchez Hidalgo M, Leonard E, Willis AE, Forconi F, Stevenson FK, Steele AJ, Coldwell MJ, Packham G.

 

Published in Cell Death & Disease on 19 July 2016: ‘Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease.’ Chernova T, Sun XM, Powley IR, Galavotti S, Grosso S, Murphy FA, Miles GJ, Cresswell L, Antonov AV, Bennett J, Nakas A, Dinsdale D, Cain K, Bushell M, Willis AE, MacFarlane M.

 

Published in Cell Death & Disease on 27 June 2016: ‘A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.’ Sbarrato T, Horvilleur E, Pöyry T, Hill K, Chaplin LC, Spriggs RV, Stoneley M, Wilson L, Jayne S, Vulliamy T, Beck D, Dokal I, Dyer MJ, Yeomans AM, Packham G, Bushell M, Wagner SD, Willis AE.

 

Published in RNA on 22 April 2016: ‘Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis’. Knight JR, Bastide A, Peretti D, Roobol A, Roobol J, Mallucci GR, Smales CM, Willis AE.

 

Published in Current Biology on 21 March 2016: ‘Translational Control: Selective upregulation of ECM components drives tumour growth’. Willis AE.

 

Published in PNAS on 22 March 2016: ‘A heme-binding domain controls regulation of ATP-dependent potassium channels’. Burton MJ, Kapetanaki SM, Chernova T, Jamieson AG, Dorlet P, Santolini J, Moody PC, Mitcheson JS, Davies NW, Schmid R, Raven EL, Storey NM.

 

 

Joern Steinert’s group:

 

Published in Scientific Reports, in press on 25 January 2016 The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors Impacts NMJ Physiology and Influences Locomotor Activity in Drosophila Larvae.’  Ziegler AB, Augustin H, Clark NL, Berthelot-Grosjean M, Simonnet MM, Steinert JR, Geillon F, Manière G, Featherstone DE and Grosjean Y.

 

 

Andrew Tobin’s group:

 

Published in The Journal of Biological Chemistry on 22 April 2016: ‘An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory’. Butcher AJ, Bradley SJ, Prihandoko R, Brooke SM, Mogg A, Bourgognon JM, Macedo-Hatch T, Edwards JM, Bottrill AR, Challiss RA, Broad LM, Felder CC, Tobin AB.

 

Published in Molecular Pharmacology in May 2016: ‘Distinct Phosphorylation Clusters Determine the Signalling Outcome of Free Fatty Acid Receptor 4/G Protein-Coupled Receptor 120’. Prihandoko R, Alvarez-Curto E, Hudson BD, Butcher AJ, Ulven T, Miller AM, Tobin AB, Milligan G.

 

Published in Nature on 31 March 2016: ‘Beta-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle’. Nuber S, Zabel U, Lorenz K, Nuber A, Milligan G, Tobin AB, Lohse MJ, Hoffmann C.

 

Published in Annual Review of Pharmacology and Toxicology in January 2016: ‘Design of Next-Generation G Protein-Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models’.   Bradley SJ, Tobin AB.

 

Published in Molecular Pharmacology in March 2016: ‘The Pharmacology and Function of Receptors for Short-Chain Fatty Acids’.   Bolognini D, Tobin AB, Milligan G, Moss CE.

 

 

Gerry Melino’s group:

 

Published in Cell Death & Differation on 1 September 2016: ‘Metabolic reprogramming during neuronal differentiation.Agostini M, Romeo F, Inoue S, Niklison-Chirou MV, Elia AJ, Dinsdale D, Morone N, Knight RA, Mak TW, Melino G.

 

Published in Ageing Research Reviews on 29 August 2016: ‘The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases.Balistreri CR, Madonna R, Melino G, Caruso C.

 

Published in Cell Death Discovery on 18 August 2016: ‘Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model.Palombo R, Savini I, Avigliano L, Madonna S, Cavani A, Albanesi C, Mauriello A, Melino G, Terrinoni A.

 

Published in Cancer Cell on 8 August 2016: ‘Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.

 

Published in Oncogene on 25 July 2016 (Epub ahead of print): ‘Human EHMT2/G9a activates p53 through methylation-independent mechanism.Rada M, Vasileva E, Lezina L, Marouco D, Antonov AV, Macip S, Melino G, Barlev NA.

 

Published in Oncotarget on 13 July 2016 (Epub ahead of print): ‘Ultraconserved long non-coding RNA uc.63 in breast cancer.Marini A, Lena AM, Panatta E, Ivan C, Han L, Liang H, Annicchiarico-Petruzzelli M, Di Daniele N, Calin GA, Candi E, Melino G.

 

Published in Aging on 8 July 2016: ‘FOXM1 regulates proliferation, senescence and oxidative stress in keratinocytes and cancer cells.Smirnov A, Panatta E, Lena A, Castiglia D, Di Daniele N, Melino G, Candi E

 

Published in Journal of European Academy of Dermatology & Venereology on 30 May 2016: ‘Cutaneous mosaicism, in KRT1 pI479T patient, caused by the somatic loss of the wild-type allele, leads to the increase in local severity of the disease’. Palombo R, Giannella E, Didona B, Annicchiarico-Petruzzelli M, Melino G, Terrinoni A.

 

Published in Oncotarget on 24 May 2016: ‘Metabolic pathways regulated by TAp73 in response to oxidative stress.Agostini M, Annicchiarico-Petruzzelli M, Melino G, Rufini A.

 

Published in Elife on 23 May 2016: ‘Damage limitation.Amelio I, Melino G.

 

Published in Cell Death Discovery on 19 May 2016: ‘Allele-specific silencing of EEC p63 mutant R304W restores p63 transcriptional activity.Novelli F, Lena AM, Panatta E, Nasser W, Shalom-Feuerstein R, Candi E, Melino G.

 

Published in Oncotarget on 18 May 2016 (Epub ahead of print): ‘The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation.Le Clorennec C, Lazrek Y, Dubreuil O, Larbouret C, Poul MA, Mondon P, Melino G, Pèlegrin A, Chardès T.

 

Published in Mechanisms of Ageing & Development on 4 May 2016 (Epub ahead of print): ‘Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases.Regina C, Panatta E, Candi E, Melino G, Amelio I, Balistreri CR, Annicchiarico-Petruzzelli M, Di Daniele N, Ruvolo G.

 

Published in Oncotarget on 22 April 2016 (E-pub ahead of print): ‘Metabolic pathways regulated by TAp73 in response to oxidative stress’. Agostini M, Annicchiarico-Petruzzelli M, Melino G, Rufini A.

 

Published in Cold Spring Harbor Perspectives in Medicine on 18 April 2016 (E-pub ahead of print): ‘Structural Evolution and Dynamics of the p53 Proteins’. Chillemi G, Kehrloesser S, Bernassola F, Desideri A, Dötsch V, Levine AJ, Melino G.

 

Published in Cell Death Differentiation on 8 April 2016 (E-pub ahead of print): ‘Metabolic reprogramming during neuronal differentiation’. Agostini M, Romeo F, Inoue S, Niklison-Chirou MV, Elia AJ, Dinsdale D, Morone N, Knight RA, Mak TW, Melino G.

 

Published in Oncogene on 24 March 2016 (E-pub ahead of print): ‘p63 controls cell migration and invasion by transcriptional regulation of MTSS1’. Giacobbe A, Compagnone M, Bongiorno-Borbone L, Antonov A, Markert EK, Zhou JH, Annicchiarico-Petruzzelli M, Melino G, Peschiaroli A.

 

Published in Cell Death & Disease on 17 March 2016: ‘p53MutaGene: an online tool to estimate the effect of p53 mutational status on gene regulation in cancer’. Amelio I, Knight RA, Lisitsa A, Melino G, Antonov AV.

 

Published in Oncotarget on 15 March 2016: ‘p73 promotes glioblastoma cell invasion by directly activating POSTN (periostin) expression’. Landré V, Antonov A, Knight R, Melino G.

 

Published in Cell Death Discovery on 29 February 2016: ‘?Np63? modulates histone methyl transferase SETDB1 to transcriptionally repress target genes in cancers.Regina C, Compagnone M, Peschiaroli A, Lena AM, Melino G, Candi E.

 

Published in Current Drug Targets on 29 Feb 2016 (E-pub ahead of print): ‘Polypharmacology of approved anticancer drugs.Amelio I, Lisitsa A, Knight RA, Melino G, Antonov AV.

 

 

Giovanna Mallucci’s group:

 

Review published online in Brain Research on 26 March 2016: ‘The UPR and synaptic dysfunction in neurodegeneration’. Freeman OJ, Mallucci GR.

 

 

Marion MacFarlane’s group:

 

Published in the British Journal of Cancer on 28 June 2016: ‘Targeting cell death signalling in cancer: minimising ‘Collateral damage’’. Fox JL, MacFarlane M.

 

Published in Oncogene on 25 April 2016 (E-pub ahead of print): ‘Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex’.  Powley IR, Hughes MA, Cain K, MacFarlane M

 

Published in Molecular Cell on 17 March 2016: ‘Co-operative and hierarchical binding of c-FLIP and Caspase-8: A unified model defines how c-FLIP isoforms differentially control cell fate’.  Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JWR, Leverkus M, Cain K, MacFarlane M.

 

 

Martin Bushell’s group:

 

Published in Cell Death & Disease on 7 April 2016: ‘The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration’. Hall AE, Lu WT, Godfrey JD, Antonov AV, Paicu C, Moxon S, Dalmay T, Wilczynska A, Muller PA and Bushell M.

 

Published in Diabetologia on 10 March 2016: ‘Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition’. Martin-Gronert MS, Fernandez-Twinn DS, Bushell M, Siddle K, Ozanne SE.

 

 

Miguel Martin’s group:

 

Published in Cell Death & Disease on 31 March 2016 (online): ‘Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease’. Lehmann S, Costa AC, Celardo I, Loh SHY and Martins LM.

 

 

Patricia Muller’s group:

 

Published in Biochemical Society Transactions on 11 April 2016: ‘Novel targets and interaction partners of mutant p53 Gain-Of-Function’. Aschauer L, Muller PA.

 

 

John Le Quesne’s group:

 

Published in The Lancet on 3 September 2016: ‘Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease’. Hiley CT, Le Quesne J, Santis G, Sharpe R, de Castro DG, Middleton G, Swanton C.

 

 

2015 Publications

 

 

Anne Willis’s group:

 

Published in Cell Death & Differentiation on 22 April 2015: ‘eIF4A1 is a promising new therapeutic target in ER-negative breast cancer’. Stoneley M, Willis AE.

 

Published in Genes & Development in September 2015: ‘A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy’.  Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JRP, Puget S, Grill J, Grundy RG, Bushell M, Willis AE.

 

Published in Oncogene in September 2015: ‘LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression’Mura M, Hopkins TG, Michael T, Abd-Latip N, Weir J, Aboagye E, Mauri F, Jameson C, Sturge J, Gabra H, Bushell M, Willis AE, Curry E, Blagden SP.

 

Published in Blood on 21 October 2015 (epub ahead of print): ‘Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation’. Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Sanchez Hidalgo M, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G.

 

 

Joern Steinert’s group:

 

Published in Journal of Neuroscience Methods on 30 April 2015: ‘Characterisation and comparison of temporal release profiles of nitric oxide generating donors’. Bradley SA, Steinert JR.

 

Published in Oxidative Medicine & Cellular Longevity on 28 June 2015: Nitric Oxide-Mediated Posttranslational Modifications: Impacts at the Synapse’. Bradley SA, Steinert JR.

 

Published in Cogent Biology on 7 September 2015: ‘Synapses and α-synuclein signalling in disease’. Breda C, Giorgini F, Steinert JR.

 

 

Gerry Melino’s group:

 

Published in Cell Death & Differentiation on 22 January 2015: ‘Essential versus accessory aspects of cell death: recommendations of the NCCD 2015’. Knight RA, Melino G, et al.

 

Published in Biochemistry in February 2015: ‘AMP-Activated Protein Kinase: Structure, Function, and Role in Pathological Processes’. Novikova DS, Garabadzhiu AV, Melino G, Barlev NA, Tribulovich VG.

 

Published in Proceedings of the National Academy of Sciences of the USA in March 2015 (Epub ahead of print): ‘p63 sustains self-renewal of mammary cancer stem cells through regulation of Sonic Hedgehog signaling’. Memmi EM, Sanarico AG, Giacobbe A, Peschiaroli A, Frezza V, Cicalese A, Pisati F, Tosoni D, Zhou H, Tonon G, Antonov A, Melino G, Pelicci PG, Bernassola F.

 

Published in Scientific Reports on 17 March 2015: ‘ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice’. Stöhr R, Mavilio M, Marino A, Casagrande V, Kappel B, Möllmann J, Menghini R, Melino G, Federici M.

 

Published in Cell Cycle on 19 March 2015: ‘TAp63gamma is required for the late stages of myogenesis’. Cefalù S, Lena AM, Vojtesek B, Musarò A, Rossi A, Melino G, Candi E.

 

Published in Journal of the European Academy of Dermatology and Venereology on 22 April 2015 (Epub ahead of print): ‘Cutaneous mosaicism, in KRT1 pI479T patient, caused by the somatic loss of the wild-type allele, leads to the increase in local severity of the disease’. Palombo R, Giannella E, Didona B, Annicchiarico-Petruzzelli M, Melino G, Terrinoni A.

 

Published in Oncotarget on 30 April 2015: ‘Polypharmacology of small molecules targeting the ubiquitin-proteasome and ubiquitin-like systems’. Amelio I, Landré V, Knight RA, Lisitsa A, Melino G, Antonov AV.

 

Published in the FEBS Journal in June 2015: ‘Transglutaminase 2 interactions with extracellular matrix proteins as probed with celiac disease autoantibodies’. Cardoso I, Stamnaes J, Andersen JT, Melino G, Iversen R, Sollid LM.

 

Published in Mini Reviews in Medicinal Chemistry on 8 June 2015: ‘Perspective on multi-target antiplatelet therapies: high content phenotypic screening as an unbiased source of novel polypharmacological strategies’. Landre V, Amelio I, Barlev NA, Knight RA, Lisitsa A, Melino G, Antonov AV.

 

Published in Oncogene on 22 June 2015: ‘ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer’. Latina A, Viticchiè G, Lena AM, Piro MC, Annicchiarico-Petruzzelli M, Melino G, Candi E.

 

Published in ACS Medicinal Chemistry Letters on 6 July 2015: ‘Discovery of Novel Isatin-Based p53 Inducers’. Davidovich P, Aksenova V, Petrova V, Tentler D, Orlova D, Smirnov S, Gurzhiy V, Okorokov AL, Garabadzhiu A, Melino G, Barlev N, Tribulovich V.

 

Published in Oncotarget on 10 July 2015: ‘Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells’. Bongiorno-Borbone L, Giacobbe A, Compagnone M, Eramo A, De Maria R, Peschiaroli A, Melino G.

 

Published in Science Signalling on 14 July 2015: ‘The interaction of heparan sulfate proteoglycans with endothelial transglutaminase-2 limits VEGF165-induced angiogenesis’. Beckouche N, Bignon M, Lelarge V, Mathivet T, Pichol-Thievend C, Berndt S, Hardouin J, Garand M, Ardidie-Robouant C, Barret A, Melino G, Lortat-Jacob H, Muller L, Monnot C, Germain S.

 

Published in Cell Death & Disease on 23 July 2015: ‘Genome-editing tools for stem cell biology’. Vasileva EA, Shuvalov OU, Garabadgiu AV, Melino G, Barlev NA.

 

Published in Drug Discovery Today on 26 July 2015: ‘Exploration of individuality in drug metabolism by high-throughput metabolomics: The fast line for personalized medicine’. Trifonova O, Knight RA, Lisitsa A, Melino G, Antonov AV.

 

Published in Science Signalling on 28 July 2015: ‘Maintaining epithelial stemness with p63’. Melino G, Memmi EM, Pelicci PG, Bernassola F.

 

Published in Cell Cycle on 3 August 2015: ‘TAp73 transcriptionally represses BNIP3 expression’. Petrova V, Mancini M, Agostini M, Knight RA, Annicchiarico-Petruzzelli M, Barlev NA, Melino G, Amelio I.

 

Published in Molecular Neurobiology on 13 August 2015: ‘How Does p73 Cause Neuronal Defects?Niklison-Chirou, Killick R, Knight RA, Nicotera P, Melino G, Agostini M.

 

Published in Trends in Biochemical Sciences in August 2015 ‘p53 family and Hypoxia inducible factors in cancer’. Amelio I, Melino G.

 

Published in Oncogene on 24 August 2015: ‘ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4’. Pieraccioli M, Nicolai S, Antonov A, Somers J, Malewicz M, Melino G, Raschellà G.

 

Published in Cell Death & Disease on 27 August 2015: ‘Transglutaminase 2–a novel inhibitor of adipogenesis’. Myneni VD, Melino G, Kaartinen MT.

 

Published in Proceedings of the National Academy of Sciences USA on 31 August 2015: ‘p63 supports aerobic respiration through hexokinase II’. Viticchiè G, Agostini M, Lena AM, Mancini M, Zhou H, Zolla L, Dinsdale D, Saintigny G, Melino G, Candi E.

 

Published in Current Gene Therapy in 2015: ‘Current genome editing tools in gene therapy: new approaches to treat cancer’. Shuvalov O, Petukhov A, Daks A, Fedorova O, Ermakov A, Melino G, Barlev NA.

 

Published in The FEBS Journal on 12 September 2015: ‘The E3 ligase Itch knockout mice show hyperproliferation and wound healing alteration’. Giamboi-Miraglia A, Cianfarani F, Cattani C, Lena AM, Serra V, Campione E, Terrinoni A, Zambruno G, Odorisio T, Di Daniele N, Melino G, Candi E.

 

Published in Cell Death & Disease on 17 September 2015: ‘The interplay between inflammation and metabolism in rheumatoid arthritis’. Chimenti MS, Triggianese P, Conigliaro P, Candi E, Melino G, Perricone R.

 

Published in Oncotarget on 22 September 2015: ‘KMT Set7/9 affects genotoxic stress response via the Mdm2 axis’. Lezina L, Aksenova V, Fedorova O, Malikova D, Shuvalov O, Antonov AV, Tentler D, Garabadgiu AV, Melino G, Barlev NA.

 

Published in Oncotarget on 22 September 2015: ‘The 26S proteasome is a multifaceted target for anti-cancer therapies’. Grigoreva TA, Tribulovich VG, Garabadzhiu AV, Melino G, Barlev NA.

 

Published in Oncogene on 19 October 2015: ‘The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain’.  D’Abramo M, Bešker N, Desideri A, Levine AJ, Melino G, Chillemi G.

 

Published in Oncotarget on 20 October 2015: ‘p73 regulates basal and starvation-induced liver metabolism in vivo’. He Z, Agostini M, Liu H, Melino G, Simon HU.

 

Published in Aging (Albany NY) on 10 November 2015 (Epub ahead of print): ‘OTX2 regulates the expression of TAp63 leading to macular and cochlear neuroepithelium development’. Palombo R, Porta G, Bruno E, Provero P, Serra V, Neduri K, Viziano A, Alessandrini M, Micarelli A, Ottaviani F, Melino G, Terrinoni A.

 

Published in Biochemical & Biophysical Research Communication on 13 November 2015: ‘Amino-terminal residues of ΔNp63, mutated in ectodermal dysplasia, are required for its transcriptional activity’. Lena AM, Duca S, Novelli F, Melino S, Annicchiarico-Petruzzelli M, Melino G, Candi E.

 

 

Giovanna Mallucci’s group:

 

Published in Cell Death & Disease in March 2015: ‘Partial restoration of protein synthesis by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity’. Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci G R.

 

Published in Acta Neuropathologica in November 2015: ‘PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia’.  Radford H, Moreno JA, Verity N, Halliday M, Mallucci GR.

 

 

John Le Quesne’s group:

 

Published in Biochemical Society Transactions on 1 December 2015: ‘Translational dysregulation in cancer: eIF4A isoforms and sequence determinants of eIF4A dependence’. Raza F, Waldron JA, Quesne JL.

 

 

Marion MacFarlane’s group:

 

Published in Cancer Research online on 3 February 2015:  ‘BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs’. Fox J, Storey A.

 

Published in Oncogene on 22 Jun 2015 [Epub ahead of print]: ‘Resistance to HSP90 inhibition involving loss of MCL1 addiction’.   Busacca S, Law EW, Powley IR, Proia DA, Sequeira M, Le Quesne J, Klabatsa A, Edwards JM, Matchett KB, Luo JL, Pringle JH, El-Tanani M, MacFarlane M, Fennell DA.

 

Published in Journal of Cellular Biochemistry on 12 May 2015:  ‘Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells’. Naik S, MacFarlane M, Sarin A.

 

Published in Cell Death Discovery on 17 August 2015: ‘Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia’. Watson AS, Riffelmacher T, Stranks A, Williams O, De Boer J, Cain K, MacFarlane M, McGouran J, Kessler B, Khandwala S, Chowdhury O, Puleston D, Phadwal K, Mortensen M, Ferguson D, Soilleux E, Woll P, Jacobsen SE, Simon AK.

 

Published in Cold Spring Harbor Protocols on 2 December 2015: ‘Biochemical Analysis of Initiator Caspase-Activating Complexes: The Apoptosome and the Death-Inducing Signaling Complex’.   Langlais C, Hughes MA, Cain K, MacFarlane M.

 

Published in Cold Spring Harbor Protocols on 2 December 2015: ‘Activation, Isolation, and Analysis of the Death-Inducing Signaling Complex’. Hughes MA, Langlais C, Cain K, MacFarlane M.

 

Published in Cold Spring Harbor Protocols on 2 December 2015: ‘In Vitro Assembly and Analysis of the Apoptosome Complex’. Langlais C, Hughes MA, Cain K, MacFarlane M.

 

 

Michal Malewicz’s group:

 

Published online on 13 March 2015 in Cell Death and Differentiation: ‘XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair’. Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K, Malewicz M.

 

 

Miguel Martin’s group:

 

Published in Experimental Cell Research on 26 February 2015: ‘A yeast model of the Parkinson’s disease-associated protein Parkin’. Pereira C, Costa V, Martins LM, Saraiva L.

 

Published in Proceedings of the National Academy of Sciences of the USA in January 2015: ‘Inhibition of oxidative metabolism leads to p53 genetic inactivation & transformation in neural stem cells’. Bartesaghi S, Graziano V, Galavotti S, Henriquez NV, Betts J, Saxena J, A D, Karlsson A, Martins LM, Capasso M, Nicotera P, Brandner S, De Laurenzi V, Salomoni P.

 

 

Patricia Muller’s group:

 

Published in Biomedicines on 15 January 2015: ‘c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences’. Viticchiè G, Muller PAJ.

 

 

2014 Publications

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.

Mura M, Hopkins TG, Michael T, Abd-Latip N, Weir J, Aboagye E, Mauri F, Jameson C, Sturge J, Gabra H, Bushell M, Willis AE, Curry E, Blagden SP.

Oncogene. 2014 Dec 22. doi: 10.1038/onc.2014.428. [Epub ahead of print]

Old case, new leads: miRNA links Kaposi’s sarcoma-associated herpesvirus with sepsis.

Lu WT, Bushell M.

Cell Death Dis. 2014 Dec 4;5:e1560. doi: 10.1038/cddis.2014.516. No abstract available.

Absence of filaggrin mutation in a patient affected by pachyonychia congenita and mild atopic dermatitis.

Terrinoni A, Giardina E, Pertusi G, Cascella R, Serra V, Bornacina C, Palombo R, Tiberio R, Gattoni M, Novelli G, Annicchiarico-Petruzzelli M, Melino G, Colombo E.

Eur J Dermatol. 2014 Dec 16. [Epub ahead of print] No abstract available.

TAp73 promotes anabolism.

Amelio I, Antonov AA, Catani MV, Massoud R, Bernassola F, Knight RA, Melino G, Rufini A.

Oncotarget. 2014 Nov 13. [Epub ahead of print]

TAp73 promotes anti-senescence-anabolism not proliferation.

Agostini M, Niklison-Chirou MV, Catani MV, Knight RA, Melino G, Rufini A.

Aging (Albany NY). 2014 Nov 13. [Epub ahead of print]

p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch.

Melino S, Bellomaria A, Nepravishta R, Paci M, Melino G.

Cell Cycle. 2014 Oct 15;13(20):3207-17. doi: 10.4161/15384101.2014.951285.

Bioinformatics analysis of the serine and glycine pathway in cancer cells.

Antonov A, Agostini M, Morello M, Minieri M, Melino G, Amelio I.

Oncotarget. 2014 Nov 30;5(22):11004-13.

MicroRNAs in human skin ageing.

Mancini M, Lena AM, Saintigny G, Mahé C, Di Daniele N, Melino G, Candi E.

Ageing Res Rev. 2014 Sep;17:9-15. doi: 10.1016/j.arr.2014.04.003. Epub 2014 Apr 28.

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.

Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F.

Hum Mol Genet. 2014 Oct 9. pii: ddu521. [Epub ahead of print]

Engineered Hyperphosphorylation of the β2-adrenoceptor Prolongs Arrestin-3 Binding and Induces Arrestin Internalization.

Zindel D, Butcher AJ, Al-Sabah S, Lanzerstorfer P, Weghuber J, Tobin AB, Bunemann M, Krasel C.

Mol Pharmacol. 2014 Nov 25. pii: mol.114.095422. [Epub ahead of print]

Characterization of novel markers of senescence and their prognostic potential in cancer.

Althubiti M, Lezina L, Carrera S, Jukes-Jones R, Giblett SM, Antonov A, Barlev N, Saldanha GS, Pritchard CA, Cain K, Macip S.

Cell Death Dis. 2014 Nov 20;5:e1528. doi: 10.1038/cddis.2014.489.

A coculture model of the lung-blood barrier: The role of activated phagocytic cells.

Luyts K, Napierska D, Dinsdale D, Klein SG, Serchi T, Hoet PH.

Toxicol In Vitro. 2014 Nov 4;29(1):234-241. doi: 10.1016/j.tiv.2014.10.024. [Epub ahead of print]

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ.

Nature. 2014 Nov 5. doi: 10.1038/nature13896. [Epub ahead of print]

The ever-evolving role of mTOR in translation.

Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A.

Semin Cell Dev Biol. 2014 Sep 26. pii: S1084-9521(14)00269-9. doi: 10.1016/j.semcdb.2014.09.014. [Epub ahead of print] Review.

The complexity of miRNA-mediated repression.

Wilczynska A, Bushell M.

Cell Death Differ. 2014 Sep 5. doi: 10.1038/cdd.2014.112. [Epub ahead of print] Review.

Regulation of miRNA strand selection: follow the leader?

Meijer HA, Smith EM, Bushell M.

Biochem Soc Trans. 2014 Aug;42(4):1135-40. doi: 10.1042/BST20140142.

Function of transcription factors at DNA lesions in DNA repair.

Malewicz M, Perlmann T.

Exp Cell Res. 2014 Aug 28. pii: S0014-4827(14)00370-X. doi: 10.1016/j.yexcr.2014.08.032. [Epub ahead of print] Review.

Targeting synaptic pathology with a novel affinity mass spectrometry approach.

Brinkmalm A, Brinkmalm G, Honer WG, Moreno JA, Jakobsson J, Mallucci GR, Zetterberg H, Blennow K, Ohrfelt A.

Mol Cell Proteomics. 2014 Oct;13(10):2584-92. doi: 10.1074/mcp.M114.040113. Epub 2014 Jun 27.

PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1.

Requejo-Aguilar R, Lopez-Fabuel I, Fernandez E, Martins LM, Almeida A, Bolaños JP.

Nat Commun. 2014 Jul 24;5:4514. doi: 10.1038/ncomms5514.

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

Andree M, Seeger JM, Schüll S, Coutelle O, Wagner-Stippich D, Wiegmann K, Wunderlich CM, Brinkmann K, Broxtermann P, Witt A, Fritsch M, Martinelli P, Bielig H, Lamkemeyer T, Rugarli EI, Kaufmann T, Sterner-Kock A, Wunderlich FT, Villunger A, Martins LM, Krönke M, Kufer TA, Utermöhlen O, Kashkar H.

EMBO J. 2014 Jul 23. pii: e201387244. [Epub ahead of print]

Screening for E3-Ubiquitin ligase inhibitors: challenges and opportunities.

Landré V, Rotblat B, Melino S, Bernassola F, Melino G.

Oncotarget. 2014 Sep 30;5(18):7988-8013.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.

Cell Death Differ. 2014 Sep 19. doi: 10.1038/cdd.2014.137. [Epub ahead of print] Review.

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense.

D’Alessandro A, Amelio I, Berkers CR, Antonov A, Vousden KH, Melino G, Zolla L.

Oncotarget. 2014 Sep 15;5(17):7722-33.

MicroRNAs and p63 in epithelial stemness.

Candi E, Amelio I, Agostini M, Melino G.

Cell Death Differ. 2014 Aug 29. doi: 10.1038/cdd.2014.113. [Epub ahead of print] Review.

KMTase Set7/9 is a critical regulator of E2F1 activity upon genotoxic stress.

Lezina L, Aksenova V, Ivanova T, Purmessur N, Antonov AV, Tentler D, Fedorova O, Garabadgiu AV, Talianidis I, Melino G, Barlev NA.

Cell Death Differ. 2014 Dec;21(12):1889-99. doi: 10.1038/cdd.2014.108. Epub 2014 Aug 15.

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour.

Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F.

Hum Mol Genet. 2014 Oct 9. pii: ddu521. [Epub ahead of print]

Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

Kern S, Agarwal S, Huber K, Gehring AP, Strödke B, Wirth CC, Brügl T, Abodo LO, Dandekar T, Doerig C, Fischer R, Tobin AB, Alam MM, Bracher F, Pradel G.

PLoS One. 2014 Sep 4;9(9):e105732. doi: 10.1371/journal.pone.0105732. eCollection 2014.

Reply to “Letter to the editor: ‘Systems biology versus reductionism in cell physiology'”.

Tobin AB, Prihandoko R.

Am J Physiol Cell Physiol. 2014 Aug 1;307(3):C310. doi: 10.1152/ajpcell.00192.2014. No abstract available.

Challenges of assigning protein kinases to in vivo phosphorylation events. Focus on “Use of LC-MS/MS and Bayes’ theorem to identify protein kinases that phosphorylate aquaporin-2 at Ser256”.

Prihandoko R, Tobin AB.

Am J Physiol Cell Physiol. 2014 Jul 15;307(2):C121-2. doi: 10.1152/ajpcell.00136.2014. Epub 2014 May 14. No abstract available.

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.

Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ.

Nature. 2014 Nov 5. doi: 10.1038/nature13896. [Epub ahead of print]

DNA damage modulates interactions between microRNAs and the 26S proteasome.

Tsimokha AS, Kulichkova VA, Karpova EV, Zaykova JJ, Aksenov ND, Vasilishina AA, Kropotov AV, Antonov A, Barlev NA.

Oncotarget. 2014 Jun 15;5(11):3555-67.

Sox6 and Otx2 Control the Specification of Substantia Nigra and Ventral Tegmental Area Dopamine Neurons.

Panman L, Papathanou M, Laguna A, Oosterveen T, Volakakis N, Acampora D, Kurtsdotter I, Yoshitake T, Kehr J, Joodmardi E, Muhr J, Simeone A, Ericson J, Perlmann T.

Cell Rep. 2014 Aug 5. pii: S2211-1247(14)00583-X. doi: 10.1016/j.celrep.2014.07.016. [Epub ahead of print]

Evaluating bias-reducing protocols for RNA sequencing library preparation.

Jackson TJ, Spriggs RV, Burgoyne NJ, Jones C, Willis AE.

BMC Genomics. 2014 Jul 7;15(1):569. doi: 10.1186/1471-2164-15-569.

Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays.

Knight RA, Gostev M, Ilisavskii S, Willis AE, Melino G, Antonov AV.

Oncotarget. 2014 Feb 15;5(3):659-66.

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease.

Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM.

Nat Cell Biol. 2014 Feb;16(2):157-66. doi: 10.1038/ncb2901. Epub 2014 Jan 19.

Targeting synaptic pathology with a novel affinity mass spectrometry approach.

Brinkmalm A, Brinkmalm G, Honer WG, Moreno JA, Jakobsson J, Mallucci GR, Zetterberg H, Blennow K, Ohrfelt A.

Mol Cell Proteomics. 2014 Jun 27. pii: mcp.M114.040113. [Epub ahead of print]

Prions: Generation and Spread Versus Neurotoxicity.

Halliday M, Radford H, Mallucci GR.

J Biol Chem. 2014 Jul 18;289(29):19862-19868. Epub 2014 May 23. Review.

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy.

Rossi M, Rotblat B, Ansell K, Amelio I, Caraglia M, Misso G, Bernassola F, Cavasotto CN, Knight RA, Ciechanover A, Melino G.

Cell Death Dis. 2014 May 1;5:e1203. doi: 10.1038/cddis.2014.113.

Challenges of assigning protein kinases to in vivo phosphorylation events. Focus on “Use of LC-MS/MS and Bayes’ theorem to identify protein kinases that phosphorylate aquaporin-2 at Ser256”.

Prihandoko R, Tobin AB.

Am J Physiol Cell Physiol. 2014 Jul 15;307(2):C121-2. doi: 10.1152/ajpcell.00136.2014. Epub 2014 May 14. No abstract available.

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4.

Butcher AJ, Hudson BD, Shimpukade B, Alvarez-Curto E, Prihandoko R, Ulven T, Milligan G, Tobin AB.

J Biol Chem. 2014 Jun 27;289(26):18451-65. doi: 10.1074/jbc.M114.568816. Epub 2014 May 9.

DRUGSURV: a resource for repositioning of approved and experimental drugs in oncology based on patient survival information.

Amelio I, Gostev M, Knight RA, Willis AE, Melino G, Antonov AV.

Cell Death Dis. 2014 Feb 6;5:e1051. doi: 10.1038/cddis.2014.9.

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease.

Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM.

Nat Cell Biol. 2014 Feb;16(2):157-66. doi: 10.1038/ncb2901. Epub 2014 Jan 19.

The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.

Roobol A, Roobol J, Carden MJ, Smith ME, Hershey JW, Bastide A, Knight JR, Willis AE, Smales CM.

Biochem J. 2014 Mar 1;458(2):213-24. doi: 10.1042/BJ20130979.

Rab11 as a modulator of synaptic transmission.

Giorgini F, Steinert JR.

Commun Integr Biol. 2013 Nov 1;6(6):e26807. doi: 10.4161/cib.26807. Epub 2013 Nov 13.

Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.

King HA, Cobbold LC, Pichon X, Pöyry T, Wilson LA, Booden H, Jukes-Jones R, Cain K, Lilley KS, Bushell M, Willis AE.

Cell Death Differ. 2014 Jan;21(1):161-71. doi: 10.1038/cdd.2013.135. Epub 2013 Oct 18.

The diverse roles of the eIF4A family: you are the company you keep.

Lu WT, Wilczynska A, Smith E, Bushell M.

Biochem Soc Trans. 2014 Feb 1;42(1):166-72. doi: 10.1042/BST20130161.

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy.

Halliday M, Mallucci GR.

Neuropharmacology. 2014 Jan;76 Pt A:169-74. doi: 10.1016/j.neuropharm.2013.08.034. Epub 2013 Sep 10.

Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson’s disease model.

Zhu JY, Vereshchagina N, Sreekumar V, Burbulla LF, Costa AC, Daub KJ, Woitalla D, Martins LM, Krüger R, Rasse TM.

PLoS One. 2013 Dec 30;8(12):e83714. doi: 10.1371/journal.pone.0083714. eCollection 2013.

Anti-oxidative stress response genes: bioinformatic analysis of their expression and relevance in multiple cancers.

Rotblat B, Grunewald TG, Leprivier G, Melino G, Knight RA.

Oncotarget. 2013 Dec;4(12):2577-90.

Mutant p53 regulates Dicer through p63-dependent and -independent mechanisms to promote an invasive phenotype.

Muller PA, Trinidad AG, Caswell PT, Norman JC, Vousden KH.

J Biol Chem. 2014 Jan 3;289(1):122-32. doi: 10.1074/jbc.M113.502138. Epub 2013 Nov 12.

Perspective: Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

Muller PA, Vousden KH

Cancer Cell. 2014 Mar 17;25(3):304-17. doi: 10.1016/j.ccr.2014.01.021. Review.

ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment.

Sánchez-Fernández G, Cabezudo S, García-Hoz C, Tobin AB, Mayor F Jr, Ribas C.

PLoS One. 2013 Dec 17;8(12):e84174. doi: 10.1371/journal.pone.0084174. eCollection 2013.

Efficacy of vemurafenib in hairy-cell leukemia.

Samuel J, Macip S, Dyer MJ.

N Engl J Med. 2014 Jan 16;370(3):286-8. doi: 10.1056/NEJMc1310849. No abstract available.

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Speedy HE, Di Bernardo MC, Sava GP, Dyer MJ, Holroyd A, Wang Y, Sunter NJ, Mansouri L, Juliusson G, Smedby KE, Roos G, Jayne S, Majid A, Dearden C, Hall AG, Mainou-Fowler T, Jackson GH, Summerfield G, Harris RJ, Pettitt AR, Allsup DJ, Bailey JR, Pratt G, Pepper C, Fegan C, Rosenquist R, Catovsky D, Allan JM, Houlston RS.

Nat Genet. 2014 Jan;46(1):56-60. doi: 10.1038/ng.2843. Epub 2013 Dec 1.

Modulation of mitochondrial bioenergetics in a skeletal muscle cell line model of mitochondrial toxicity.

Dott W, Mistry P, Wright J, Cain K, Herbert KE.

Redox Biol. 2014 Jan 10;2:224-33. doi: 10.1016/j.redox.2013.12.028. eCollection 2014.

Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays.

Knight RA, Gostev M, Ilisavskii S, Willis AE, Melino G, Antonov AV.

Oncotarget. 2014 Jan 21. [Epub ahead of print]

AERS spider: an online interactive tool to mine statistical associations in Adverse Event Reporting System

Igor Grigoriev, Wolfgang zu Castell, Philipp Tsvetkov, Alexey V. Antonov

Article first published online: 12 Feb 2014

DOI: 10.1002/pds.3561

Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells.

Mong J, Panman L, Alekseenko Z, Kee N, Stanton LW, Ericson J, Perlmann T.

Stem Cells. 2014 Mar;32(3):609-22. doi: 10.1002/stem.1585.

The Pathogenic Mechanism of the Mycobacterium ulcerans Virulence Factor, Mycolactone, Depends on Blockade of Protein Translocation into the ER.

Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE.

PLoS Pathog. 2014 Apr 3;10(4):e1004061. doi: 10.1371/journal.ppat.1004061. eCollection 2014 Apr.

Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.

Burbulla LF, Fitzgerald JC, Stegen K, Westermeier J, Thost AK, Kato H, Mokranjac D, Sauerwald J, Martins LM, Woitalla D, Rapaport D, Riess O, Proikas-Cezanne T, Rasse TM, Krüger R.

Cell Death Dis. 2014 Apr 17;5:e1180. doi: 10.1038/cddis.2014.103.

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease.

Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM.

Nat Cell Biol. 2014 Feb;16(2):157-66. doi: 10.1038/ncb2901. Epub 2014 Jan 19.

Downregulation of IRS-1 in adipose tissue of offspring of obese mice is programmed cell-autonomously through post-transcriptional mechanisms.

Fernandez-Twinn DS, Alfaradhi MZ, Martin-Gronert MS, Duque-Guimaraes DE, Piekarz A, Ferland-McCollough D, Bushell M, Ozanne SE.

Mol Metab. 2014 Jan 20;3(3):325-33. doi: 10.1016/j.molmet.2014.01.007. eCollection 2014 Jun.

Modulation of the Sensitivity of Jurkat T-Cells to Inhibition of Protein Synthesis by Tumor Necrosis Factor α-Related Apoptosis-Inducing Ligand.

Elia A, Powley IR, Macfarlane M, Clemens MJ.

J Interferon Cytokine Res. 2014 Apr 14. [Epub ahead of print]

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy.

Rossi M, Rotblat B, Ansell K, Amelio I, Caraglia M, Misso G, Bernassola F, Cavasotto CN, Knight RA, Ciechanover A, Melino G.

Cell Death Dis. 2014 May 1;5:e1203. doi: 10.1038/cddis.2014.113.

CRISPR: a new method for genetic engineering – A prokaryotic immune component may potentially open a new era of gene silencing.

Amelio I, Melino G.

Cell Death Differ. 2014 Apr 4. doi: 10.1038/cdd.2014.39. [Epub ahead of print] No abstract available.

p63 transcriptionally regulates the expression of matrix metallopeptidase 13.

Celardo I, Antonov A, Amelio I, Annicchiarico-Petruzzelli M, Melino G.

Oncotarget. 2014 Mar 15;5(5):1279-89.

Serine and glycine metabolism in cancer.

Amelio I, Cutruzzolá F, Antonov A, Agostini M, Melino G.

Trends Biochem Sci. 2014 Apr;39(4):191-198. doi: 10.1016/j.tibs.2014.02.004. Epub 2014 Mar 20. Review.

TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1843-8. doi: 10.1073/pnas.1323416111. Epub 2014 Jan 21.

Prion protein facilitates synaptic vesicle release by enhancing release probability.

Robinson SW, Nugent ML, Dinsdale D, Steinert JR.

Hum Mol Genet. 2014 Apr 28. [Epub ahead of print]

Employing novel animal models in the design of clinically efficacious GPCR ligands.

Bradley SJ, Riaz SA, Tobin AB.

Curr Opin Cell Biol. 2014 Apr;27C:117-125. doi: 10.1016/j.ceb.2013.12.002. Epub 2013 Dec 31. Review.

Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation.

Graciotti M, Alam M, Solyakov L, Schmid R, Burley G, Bottrill AR, Doerig C, Cullis P, Tobin AB.

PLoS One. 2014 Mar 21;9(3):e85391. doi: 10.1371/journal.pone.0085391. eCollection 2014.

Breaking good: the inexorable rise of BTK inhibitors in the treatment of chronic lymphocytic leukaemia.

Hutchinson CV, Dyer MJ.

Br J Haematol. 2014 Apr 18. doi: 10.1111/bjh.12895. [Epub ahead of print]

 

 

 

 

2013 Publications

miRNAs-19b, -29b-2* and -339-5p Show an Early and Sustained Up-Regulation in Ischemic Models of Stroke.

Dhiraj DK, Chrysanthou E, Mallucci GR, Bushell M.

PLoS One. 2013 Dec 20;8(12):e83717. doi: 10.1371/journal.pone.0083717. eCollection 2013.

Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing.

Kamenska A, Lu WT, Kubacka D, Broomhead H, Minshall N, Bushell M, Standart N.

Nucleic Acids Res. 2013 Dec 13. [Epub ahead of print]

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.

Horvilleur E, Sbarrato T, Hill K, Spriggs RV, Screen M, Goodrem PJ, Sawicka K, Chaplin LC, Touriol C, Packham G, Potter KN, Dirnhofer S, Tzankov A, Dyer MJ, Bushell M, Macfarlane M, Willis AE.

Leukemia. 2013 Oct 18. doi: 10.1038/leu.2013.295. [Epub ahead of print]

Lysine-specific modifications of p53: a matter of life and death?

Marouco D, Garabadgiu AV, Melino G, Barlev NA.

Oncotarget. 2013 Oct;4(10):1556-71.

miR-24 affects hair follicle morphogenesis targeting Tcf-3.

Amelio I, Lena AM, Bonanno E, Melino G, Candi E.

Cell Death Dis. 2013 Nov 14;4:e922. doi: 10.1038/cddis.2013.426.

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor.

Niklison-Chirou MV, Steinert JR, Agostini M, Knight RA, Dinsdale D, Cattaneo A, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18952-7. doi: 10.1073/pnas.1221172110. Epub 2013 Nov 4.

p73 regulates serine biosynthesis in cancer.

Amelio I, Markert EK, Rufini A, Antonov AV, Sayan BS, Tucci P, Agostini M, Mineo TC, Levine AJ, Melino G.

Oncogene. 2013 Nov 4. doi: 10.1038/onc.2013.456. [Epub ahead of print]

ITCH deficiency protects from diet-induced obesity.

Marino A, Menghini R, Fabrizi M, Casagrande V, Mavilio M, Stoehr R, Candi E, Mauriello A, Moreno-Navarrete JM, Gómez-Serrano M, Peral B, Melino G, Lauro R, Fernandez Real JM, Federici M.

Diabetes. 2013 Oct 29. [Epub ahead of print]

MicroRNAs, miR-154, miR-299-5p, miR-376a, miR-376c, miR-377, miR-381, miR-487b, miR-485-3p, miR-495 and miR-654-3p, mapped to the 14q32.31 locus, regulate proliferation, apoptosis, migration and invasion in metastatic prostate cancer cells.

Formosa A, Markert EK, Lena AM, Italiano D, Finazzi-Agro’ E, Levine AJ, Bernardini S, Garabadgiu AV, Melino G, Candi E.

Oncogene. 2013 Oct 28. doi: 10.1038/onc.2013.451. [Epub ahead of print]

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.

Velletri T, Romeo F, Tucci P, Peschiaroli A, Annicchiarico-Petruzzelli M, Niklison-Chirou MV, Amelio I, Knight RA, Mak TW, Melino G, Agostini M.

Cell Cycle. 2013 Nov 15;12(22):3564-73. doi: 10.4161/cc.26771. Epub 2013 Oct 10.

Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson’s disease triggered by mitochondrial stress.

Moisoi N, Fedele V, Edwards J, Martins LM.

Neuropharmacology. 2013 Oct 23;77C:350-357. doi: 10.1016/j.neuropharm.2013.10.009. [Epub ahead of print]

Drosophila ref(2)P is required for the parkin-mediated suppression of mitochondrial dysfunction in pink1 mutants.

de Castro IP, Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM.

Cell Death Dis. 2013 Oct 24;4:e873. doi: 10.1038/cddis.2013.394.

Mutant p53 regulates Dicer through p63 dependent and independent mechanisms to promote an invasive phenotype.

Muller PA, Trinidad AG, Caswell PT, Norman JC, Vousden KH.

J Biol Chem. 2013 Nov 12. [Epub ahead of print]

The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G.

Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26.

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice.

Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR.

Sci Transl Med. 2013 Oct 9;5(206):206ra138.

Metabolic profiling of human CD4+ cells following treatment with methotrexate and anti-TNF-α infliximab.

Chimenti MS, Tucci P, Candi E, Perricone R, Melino G, Willis AE.

Cell Cycle. 2013 Sep 15;12(18):3025-36. doi: 10.4161/cc.26067. Epub 2013 Aug 19.

Rapamycin regulates biochemical metabolites.

Tucci P, Porta G, Agostini M, Antonov A, Garabadgiu AV, Melino G, Willis AE.

Cell Cycle. 2013 Aug 1;12(15):2454-67. doi: 10.4161/cc.25450. Epub 2013 Jun 28.

A perspective on mammalian upstream open reading frame function.

Somers J, Pöyry T, Willis AE.

Int J Biochem Cell Biol. 2013 Aug;45(8):1690-700. doi: 10.1016/j.biocel.2013.04.020. Epub 2013 Apr 25.

Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting.

Hertz MI, Landry DM, Willis AE, Luo G, Thompson SR.

Mol Cell Biol. 2013 Mar;33(5):1016-26. doi: 10.1128/MCB.00879-12. Epub 2012 Dec 28.

A perspective on mammalian upstream open reading frame function.

Somers J, Pöyry T, Willis AE.

Int J Biochem Cell Biol. 2013 Apr 25. doi:pii: S1357-2725(13)00125-8. 10.1016/j.biocel.2013.04.020. [Epub ahead of print]

Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.

Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M.

Science. 2013 Apr 5;340(6128):82-5. doi: 10.1126/science.1231197.

Active regulator of SIRT1 is required for ribosome biogenesis and function.

Knight JR, Willis AE, Milner J.

Nucleic Acids Res. 2013 Apr 1;41(7):4185-97. doi: 10.1093/nar/gkt129. Epub 2013 Mar 5.

Pulmonary toxicity of carbon nanotubes and asbestos – Similarities and differences.

Donaldson K, Poland CA, Murphy FA, Macfarlane M, Chernova T, Schinwald A.

Adv Drug Deliv Rev. 2013 Jul 27. doi:pii: S0169-409X(13)00168-3. 10.1016/j.addr.2013.07.014. [Epub ahead of print]

A caspase-3 ‘death-switch’ in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers.

Simpson KL, Cawthorne C, Zhou C, Hodgkinson CL, Walker MJ, Trapani F, Kadirvel M, Brown G, Dawson MJ, Macfarlane M, Williams KJ, Whetton AD, Dive C.

Cell Death Dis. 2013 May 2;4:e613. doi: 10.1038/cddis.2013.137.

Isolation, characterisation and reconstitution of cell death signalling complexes.

Hughes MA, Langlais C, Cain K, Macfarlane M.

Methods. 2013 Jun 1;61(2):98-104. doi: 10.1016/j.ymeth.2013.02.006. Epub 2013 Feb 26.

Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response.

Melis MH, Simpson KL, Dovedi SJ, Welman A, Macfarlane M, Dive C, Honeychurch J, Illidge TM.

Cell Death Differ. 2013 May;20(5):765-73. doi: 10.1038/cdd.2013.8. Epub 2013 Feb 15.

Targeting the unfolded protein response in neurodegeneration: A new approach to therapy.

Halliday M, Mallucci GR.

Neuropharmacology. 2013 Sep 10. doi:pii: S0028-3908(13)00401-2. 10.1016/j.neuropharm.2013.08.034. [Epub ahead of print]

Unravelling mitochondrial pathways to Parkinson’s disease.

Celardo I, Martins LM, Gandhi S.

Br J Pharmacol. 2013 Sep 30. doi: 10.1111/bph.12433. [Epub ahead of print]

Insights into mitochondrial quality control pathways and Parkinson’s disease.

Lehmann S, Martins LM.

J Mol Med (Berl). 2013 Jun;91(6):665-71. doi: 10.1007/s00109-013-1044-y. Epub 2013 May 4.

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson’s disease.

Costa AC, Loh SH, Martins LM.

Cell Death Dis. 2013 Jan 17;4:e467. doi: 10.1038/cddis.2012.205.

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation.

Velletri T, Romeo F, Tucci P, Peschiaroli A, Annicchiarico-Petruzzelli M, Niklison-Chirou MV, Amelio I, Knight RA, Mak TW, Melino G, Agostini M.

Cell Cycle. 2013 Oct 10;12(22). [Epub ahead of print]

Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation.

Pieraccioli M, Imbastari F, Antonov A, Melino G, Raschellà G.

Cell Cycle. 2013 Jul 15;12(14):2309-20. doi: 10.4161/cc.25405.

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene.

He Z, Liu H, Agostini M, Yousefi S, Perren A, Tschan MP, Mak TW, Melino G, Simon HU.

Cell Death Differ. 2013 Oct;20(10):1415-24. doi: 10.1038/cdd.2013.104. Epub 2013 Aug 2.

DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity.

Moiseeva TN, Bottrill A, Melino G, Barlev NA.

Oncotarget. 2013 Sep;4(9):1338-1348.

Functions of TAp63 and p53 in restraining the development of metastatic cancer.

Tan EH, Morton JP, Timpson P, Tucci P, Melino G, Flores ER, Sansom OJ, Vousden KH, Muller PA.

Oncogene. 2013 Jul 22. doi: 10.1038/onc.2013.287. [Epub ahead of print]

Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity.

Trinidad AG, Muller PA, Cuellar J, Klejnot M, Nobis M, Valpuesta JM, Vousden KH.

Mol Cell. 2013 Jun 27;50(6):805-17. doi: 10.1016/j.molcel.2013.05.002. Epub 2013 Jun 6.

p53 mutations in cancer.

Muller PA, Vousden KH.

Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641. Review.

Rapamycin regulates biochemical metabolites.

Tucci P, Porta G, Agostini M, Antonov A, Garabadgiu AV, Melino G, Willis AE.

Cell Cycle. 2013 Aug 1;12(15):2454-67. doi: 10.4161/cc.25450. Epub 2013 Jun 28.

Activation of miR200 by c-Myb depends on ZEB1 expression and miR200 promoter methylation.

Pieraccioli M, Imbastari F, Antonov A, Melino G, Raschellà G.

Cell Cycle. 2013 Jun 24;12(14). [Epub ahead of print]

Caspase-1 is a novel target of p63 in tumor suppression.

Celardo I, Grespi F, Antonov A, Bernassola F, Garabadgiu AV, Melino G, Amelio I.

Cell Death Dis. 2013 May 23;4:e645. doi: 10.1038/cddis.2013.175.

PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome.

Antonov AV, Krestyaninova M, Knight RA, Rodchenkov I, Melino G, Barlev NA.

Oncogene. 2013 May 20. doi: 10.1038/onc.2013.119. [Epub ahead of print]

Analysis of the oligomeric state and transactivation potential of TAp73α.

Luh LM, Kehrloesser S, Deutsch GB, Gebel J, Coutandin D, Schäfer B, Agostini M, Melino G, Dötsch V.

Cell Death Differ. 2013 Aug;20(8):1008-16. doi: 10.1038/cdd.2013.23. Epub 2013 Mar 29.

p63 regulates glutaminase 2 expression.

Giacobbe A, Bongiorno-Borbone L, Bernassola F, Terrinoni A, Markert EK, Levine AJ, Feng Z, Agostini M, Zolla L, Agrò AF, Notterman DA, Melino G, Peschiaroli A.

Cell Cycle. 2013 May 1;12(9):1395-405. doi: 10.4161/cc.24478. Epub 2013 Apr 10.

Analysis of the oligomeric state and transactivation potential of TAp73α

Luh LM, Kehrloesser S, Deutsch GB, Gebel J, Coutandin D, Schäfer B, Agostini M, Melino G, Dötsch V.

Cell Death Differ. 2013 Mar 29. doi: 10.1038/cdd.2013.23. [Epub ahead of print]

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.

Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agró A, Melino G, Willis A.

Cell Death Dis. 2013 Mar 21;4:e549. doi: 10.1038/cddis.2013.76.

Actin-binding protein alpha-actinin 4 (ACTN4) is a transcriptional co-activator of RelA/p65 sub-unit of NF-kB.

Aksenova V, Turoverova L, Khotin M, Magnusson KE, Tulchinsky E, Melino G, Pinaev GP, Barlev N, Tentler D.

Oncotarget. 2013 Feb;4(2):362-72.

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling.

Harris IS, Blaser H, Moreno J, Treloar AE, Gorrini C, Sasaki M, Mason JM, Knobbe CB, Rufini A, Hallé M, Elia AJ, Wakeham A, Tremblay ML, Melino G, Done S, Mak TW.

Oncogene. 2013 Feb 25. doi: 10.1038/onc.2013.24. [Epub ahead of print]

Senescence and aging: the critical roles of p53.

Rufini A, Tucci P, Celardo I, Melino G.

Oncogene. 2013 Feb 18. doi: 10.1038/onc.2012.640. [Epub ahead of print]

MIRUMIR: an online tool to test microRNAs as biomarkers to predict survival in cancer using multiple clinical data sets.

Antonov AV, Knight RA, Melino G, Barlev NA, Tsvetkov PO.

Cell Death Differ. 2013 Feb;20(2):367. doi: 10.1038/cdd.2012.137. Epub 2012 Nov 23. No abstract available.

PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome.

Antonov AV, Krestyaninova M, Knight RA, Rodchenkov I, Melino G, Barlev NA.

Oncogene. 2013 May 20. doi: 10.1038/onc.2013.119. [Epub ahead of print]

Caspase-1 is a novel target of p63 in tumor suppression.

Celardo I, Grespi F, Antonov A, Bernassola F, Garabadgiu AV, Melino G, Amelio I.

Cell Death Dis. 2013 May 23;4:e645. doi: 10.1038/cddis.2013.175.

Protection from noise-induced hearing loss by Kv2.2 potassium currents in the central medial olivocochlear system.

Tong H, Kopp-Scheinpflug C, Pilati N, Robinson SW, Sinclair JL, Steinert JR, Barnes-Davies M, Allfree R, Grubb BD, Young SM Jr, Forsythe ID.

J Neurosci. 2013 May 22;33(21):9113-21. doi: 10.1523/JNEUROSCI.5043-12.2013.

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism.

Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G.

Mol Pharmacol. 2013 Nov;84(5):710-725. Epub 2013 Aug 26.

BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis.

Weber K, Harper N, Schwabe J, Cohen GM.

Cell Rep. 2013 Oct 9. doi:pii: S2211-1247(13)00518-4. 10.1016/j.celrep.2013.09.010. [Epub ahead of print]

Evaluation and critical assessment of putative MCL-1 inhibitors.

Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM.

Cell Death Differ. 2013 Nov;20(11):1475-84. doi: 10.1038/cdd.2013.79. Epub 2013 Jul 5.

Sabutoclax (BI97C1) and BI112D1, Putative Inhibitors of MCL-1, Induce Mitochondrial Fragmentation Either Upstream of or Independent of Apoptosis.

Varadarajan S, Butterworth M, Wei J, Pellecchia M, Dinsdale D, Cohen GM.

Neoplasia. 2013 May;15(5):568-78.

Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis.

Varadarajan S, Tanaka K, Smalley JL, Bampton ET, Pellecchia M, Dinsdale D, Willars GB, Cohen GM.

PLoS One. 2013;8(2):e56603. doi: 10.1371/journal.pone.0056603. Epub 2013 Feb 15.

Enhancement of CD154/IL4 proliferation by the T follicular helper (Tfh) cytokine, IL21 and increased numbers of circulating cells resembling Tfh cells in chronic lymphocytic leukaemia.

Ahearne MJ, Willimott S, Piñon L, Kennedy DB, Miall F, Dyer MJ, Wagner SD.

Br J Haematol. 2013 May 27. doi: 10.1111/bjh.12401. [Epub ahead of print]

Precision medicines for B-cell leukaemias and lymphomas; progress and potential pitfalls.

Dyer MJ, Vogler M, Samuel J, Jayne S, Wagner S, Pritchard C, Macip S.

Br J Haematol. 2013 Mar;160(6):725-33. doi: 10.1111/bjh.12219. Epub 2013 Jan 24.

The detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies.

Dyer MJ.

Methods Mol Biol. 2013;971:123-33. doi: 10.1007/978-1-62703-269-8_7.

BCL7A protein expression in normal and malignant lymphoid tissues.

Ramos-Medina R, Montes-Moreno S, Maestre L, Cañamero M, Rodríguez-Pinilla M, Martínez-Torrecuadrada J, Piris MÁ, Majid A, Dyer MJ, Pulford K, Roncador G.

Br J Haematol. 2013 Jan;160(1):106-9. doi: 10.1111/bjh.12080. Epub 2012 Oct 9. No abstract available.

Human telomeres that carry an integrated copy of human herpesvirus 6 are often short and unstable, facilitating release of the viral genome from the chromosome.

Huang Y, Hidalgo-Bravo A, Zhang E, Cotton VE, Mendez-Bermudez A, Wig G, Medina-Calzada Z, Neumann R, Jeffreys AJ, Winney B, Wilson JF, Clark DA, Dyer MJ, Royle NJ.

Nucleic Acids Res. 2013 Sep 19. [Epub ahead of print]

ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

Vogler M, Dinsdale D, Dyer MJ, Cohen GM.

Br J Haematol. 2013 Oct;163(1):139-42. doi: 10.1111/bjh.12457. Epub 2013 Jul 4. No abstract available.

Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity.

Dudek KM, Suter L, Darras VM, Marczylo EL, Gant TW.

Biochem J. 2013 Apr 16. [Epub ahead of print]

miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress.

Lezina L, Purmessur N, Antonov AV, Ivanova T, Karpova E, Krishan K, Ivan M, Aksenova V, Tentler D, Garabadgiu AV, Melino G, Barlev NA.

Cell Death Dis. 2013 Dec 12;4:e953. doi: 10.1038/cddis.2013.483

 

 

 

2012 Publications

 

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1.

Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, Cohen GM.

Cell Death Differ. 2012 Sep;19(9):1424-34. doi: 10.1038/cdd.2012.16. Epub 2012 Feb 24.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

Varadarajan S, Bampton ET, Smalley JL, Tanaka K, Caves RE, Butterworth M, Wei J, Pellecchia M, Mitcheson J, Gant TW, Dinsdale D, Cohen GM.

Cell Death Differ. 2012 Dec;19(12):1896-907. doi: 10.1038/cdd.2012.108. Epub 2012 Sep 7.

miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.

Amelio I, Lena AM, Viticchiè G, Shalom-Feuerstein R, Terrinoni A, Dinsdale D, Russo G, Fortunato C, Bonanno E, Spagnoli LG, Aberdam D, Knight RA, Candi E, Melino G.

J Cell Biol. 2012 Oct 15;199(2):347-63. doi: 10.1083/jcb.201203134.

TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW.

Genes Dev. 2012 Sep 15;26(18):2009-14. doi: 10.1101/gad.197640.112.

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster.

Pimenta de Castro I, Costa AC, Lam D, Tufi R, Fedele V, Moisoi N, Dinsdale D, Deas E, Loh SH, Martins LM.

Cell Death Differ. 2012 Aug;19(8):1308-16. doi: 10.1038/cdd.2012.5. Epub 2012 Feb 3.

The Drosophila inner-membrane protein PMI controls cristae biogenesis and mitochondrial diameter.

Macchi M, El Fissi N, Tufi R, Bentobji M, Liévens JC, Martins LM, Royet J, Rival T.

J Cell Sci. 2012 Dec 21. [Epub ahead of print]

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death.

Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, Schwabe JW, Cain K, Macfarlane M.

Mol Cell. 2012 Jul 27;47(2):291-305. Epub 2012 Jun 7.

Glucose–a sweet way to die: metabolic switching modulates tumor cell death.

MacFarlane M, Robinson GL, Cain K.

Cell Cycle. 2012 Nov 1;11(21):3919-25. doi: 10.4161/cc.21804. Epub 2012 Sep 14.

The ‘complexities’ of life and death: Death receptor signalling platforms.

Dickens LS, Powley IR, Hughes MA, Macfarlane M.

Exp Cell Res. 2012 Jul 1;318(11):1269-77. Epub 2012 Apr 17.

RNA Binding Protein/RNA Element Interactions and the Control of Translation.

Pichon X, Wilson LA, Stoneley M, Bastide A, King HA, Somers J, Willis AE.

Curr Protein Pept Sci. 2012 Jun 1;13(4):294-304.

Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo.

Young AM, Archibald KM, Tookman LA, Pool A, Dudek K, Jones C, Williams SL, Pirlo KJ, Willis AE, Lockley M, McNeish IA.

Mol Ther. 2012 Sep;20(9):1676-88. doi: 10.1038/mt.2012.116. Epub 2012 Jun 26.

microRNAs in cancer management.

Kong YW, Ferland-McCollough D, Jackson TJ, Bushell M.

Lancet Oncol. 2012 Jun;13(6):e249-58.

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.

Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.

Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.

Sustained translational repression by eIF2α-P mediates prion neurodegeneration.

Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR.

Nature. 2012 May 6;485(7399):507-11. doi: 10.1038/nature11058.

Relative expression of TAp73 and ΔNp73 isoforms.

Conforti F, Yang AL, Agostini M, Rufini A, Tucci P, Nicklison-Chirou MV, Grespi F, Velletri T, Knight RA, Melino G, Sayan BS.

Aging (Albany NY). 2012 Mar;4(3):202-5.

Resuscitating supplementary information: is the solution a two-for-one offer?

Knight RA, Melino G.

Cell Death Differ. 2012 Feb;19(2):185. doi: 10.1038/cdd.2011.177. No abstract available.

Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.

Robinson GL, Dinsdale D, Macfarlane M, Cain K.

Oncogene. 2012 Feb 6. doi: 10.1038/onc.2012.13.

The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity.

Malatesta M, Peschiaroli A, Memmi EM, Zhang J, Antonov A, Green DR, Barlev NA, Garabadgiu AV, Zhou P, Melino G, Bernassola F.

Oncogene. 2012 Oct 22. doi: 10.1038/onc.2012.463. [Epub ahead of print]

MicroRNA-203 contributes to skin re-epithelialization.

Viticchiè G, Lena AM, Cianfarani F, Odorisio T, Annicchiarico-Petruzzelli M, Melino G, Candi E.

Cell Death Dis. 2012 Nov 29;3:e435. doi: 10.1038/cddis.2012.174.

The “Sharp” blade against HIF-mediated metastasis.

Amelio I, Melino G.

Cell Cycle. 2012 Dec 15;11(24):4530-5. doi: 10.4161/cc.22820. Epub 2012 Nov 27.

NRF2 and p53: Januses in cancer?

Rotblat B, Melino G, Knight RA.

Oncotarget. 2012 Nov;3(11):1272-83.

p63 the guardian of human reproduction.

Amelio I, Grespi F, Annicchiarico-Petruzzelli M, Melino G.

Cell Cycle. 2012 Dec 15;11(24):4545-51. doi: 10.4161/cc.22819. Epub 2012 Nov 19.

Tissue-specific expression of p73 C-terminal isoforms in mice.

Grespi F, Amelio I, Tucci P, Annicchiarico-Petruzzelli M, Melino G.

Cell Cycle. 2012 Dec 1;11(23):4474-83. doi: 10.4161/cc.22787. Epub 2012 Nov 16.

PIR2/Rnf144B regulates epithelial homeostasis by mediating degradation of p21(WAF1) and p63.

Conforti F, Li Yang A, Cristina Piro M, Mellone M, Terrinoni A, Candi E, Tucci P, Thomas GJ, Knight RA, Melino G, Sayan BS.

Oncogene. 2012 Nov 5. doi: 10.1038/onc.2012.497. [Epub ahead of print]

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer.

Tucci P, Agostini M, Grespi F, Markert EK, Terrinoni A, Vousden KH, Muller PA, Dötsch V, Kehrloesser S, Sayan BS, Giaccone G, Lowe SW, Takahashi N, Vandenabeele P, Knight RA, Levine AJ, Melino G.

Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15312-7. Epub 2012 Sep 4.

Relative expression of TAp73 and ΔNp73 isoforms.

Conforti F, Yang AL, Agostini M, Rufini A, Tucci P, Nicklison-Chirou MV, Grespi F, Velletri T, Knight RA, Melino G, Sayan BS.

Aging (Albany NY). 2012 Mar;4(3):202-5.

Resuscitating supplementary information: is the solution a two-for-one offer?

Knight RA, Melino G.

Cell Death Differ. 2012 Feb;19(2):185. doi: 10.1038/cdd.2011.177. No abstract available.

microRNA-34a regulates neurite outgrowth, spinal morphology, and function.

Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, Forsythe ID, Young KW, Ventura A, Concepcion CP, Han YC, Candi E, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21099-104. doi: 10.1073/pnas.1112063108. Epub 2011 Dec 12.

Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor.

Chen YJ, Oldfield S, Butcher AJ, Tobin AB, Saxena K, Gurevich VV, Benovic JL, Henderson G, Kelly E.

J Neurochem. 2013 Jan;124(2):189-99. doi: 10.1111/jnc.12071. Epub 2012 Nov 30.

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion.

Guttery DS, Poulin B, Ferguson DJ, Szöőr B, Wickstead B, Carroll PL, Ramakrishnan C, Brady D, Patzewitz EM, Straschil U, Solyakov L, Green JL, Sinden RE, Tobin AB, Holder AA, Tewari R.

PLoS Pathog. 2012 Sep;8(9):e1002948. doi: 10.1371/journal.ppat.1002948. Epub 2012 Sep 20.

Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor.

Gregory KJ, Sexton PM, Tobin AB, Christopoulos A.

J Biol Chem. 2012 Oct 26;287(44):37066-77. doi: 10.1074/jbc.M112.408534. Epub 2012 Sep 10.

An evolutionary perspective on the kinome of malaria parasites.

Talevich E, Tobin AB, Kannan N, Doerig C.

Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2607-18. doi: 10.1098/rstb.2012.0014. Review.

Insights into the Plasmodium falciparum schizont phospho-proteome.

Lasonder E, Treeck M, Alam M, Tobin AB.

Microbes Infect. 2012 Aug;14(10):811-9. doi: 10.1016/j.micinf.2012.04.008. Epub 2012 May 5. Review.

Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling.

Simon V, Oner SS, Cohen-Tannoudji J, Tobin AB, Lanier SM.

Mol Pharmacol. 2012 Jul;82(1):17-26. doi: 10.1124/mol.111.075523. Epub 2012 Mar 30.

A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development.

Guttery DS, Ferguson DJ, Poulin B, Xu Z, Straschil U, Klop O, Solyakov L, Sandrini SM, Brady D, Nieduszynski CA, Janse CJ, Holder AA, Tobin AB, Tewari R.

PLoS Pathog. 2012 Feb;8(2):e1002554. doi: 10.1371/journal.ppat.1002554. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2012 Mar;8(3). doi: 10.1371/annotation/ef70d427-0816-4a63-aeaf-874b734793b0.

Physiological role of G-protein coupled receptor phosphorylation.

Butcher AJ, Kong KC, Prihandoko R, Tobin AB.

Handb Exp Pharmacol. 2012;(208):79-94. doi: 10.1007/978-3-642-23274-9_5. Review.

Spatiotemporal and functional characterisation of the Plasmodium falciparum cGMP-dependent protein kinase.

Hopp CS, Flueck C, Solyakov L, Tobin A, Baker DA.

PLoS One. 2012;7(11):e48206. doi: 10.1371/journal.pone.0048206. Epub 2012 Nov 5.

 

 

2011 Publications

 

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis.

Kress TR, Cannell IG, Brenkman AB, Samans B, Gaestel M, Roepman P, Burgering BM, Bushell M, Rosenwald A, Eilers M.

Mol Cell. 2011 Feb 18;41(4):445-57.

 

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms.

Feoktistova M, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M.

Mol Cell. 2011 Aug 5;43(3):449-63.

 

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P.

Mol Cell. 2011 Aug 5;43(3):432-48. Epub 2011 Jul 7. Erratum in: Mol Cell. 2011 Aug 19;43(4):689.

 

Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

Chernova T, Steinert JR, Richards P, Mistry R, Challiss RA, Jukes-Jones R, Cain K, Smith AG, Forsythe ID.

Mol Pharmacol. 2011 May;79(5):844-54. Epub 2011 Feb 15.

 

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington’s disease.

Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, Glynn P, Cain K, Kyriacou CP, Giorgini F, Nicotera P.

Cell Death Differ. 2011 Feb;18(2):191-200. Epub 2010 Nov 19. Erratum in: Cell Death Differ. 2011 May;18(5):914.

 

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation.

Vogler M, Hamali HA, Sun XM, Bampton ET, Dinsdale D, Snowden RT, Dyer MJ, Goodall AH, Cohen GM.

Blood. 2011 Jun 30;117(26):7145-54. Epub 2011 May 11.

 

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein.

Vogler M, Dickens D, Dyer MJ, Owen A, Pirmohamed M, Cohen GM.

Biochem Biophys Res Commun. 2011 May 6;408(2):344-9. Epub 2011 Apr 13.

 

Lung exposure to nanoparticles modulates an asthmatic response in a mouse model.

Hussain S, Vanoirbeek JA, Luyts K, De Vooght V, Verbeken E, Thomassen LC, Martens JA, Dinsdale D, Boland S, Marano F, Nemery B, Hoet PH.

Eur Respir J. 2011 Feb;37(2):299-309. Epub 2010 Jun 7.

 

MicroRNA expression profiling in patients with lamin A/C-associated muscular dystrophy.

Sylvius N, Bonne G, Straatman K, Reddy T, Gant TW, Shackleton S.

FASEB J. 2011 Sep 28. [Epub ahead of print]

 

Skills and training for the 21st century chemical toxicologist.

Gant TW.

Chem Res Toxicol. 2011 Jul 18;24(7):985-7. No abstract available.

 

Rescuing neurons in prion disease.

Verity NC, Mallucci GR.

Biochem J. 2011 Jan 1;433(1):19-29. Review.

 

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P.

Mol Cell. 2011 Aug 5;43(3):432-48. Epub 2011 Jul 7. Erratum in: Mol Cell. 2011 Aug 19;43(4):689.

 

Disassembly of the JIP1/JNK molecular scaffold by caspase-3-mediated cleavage of JIP1 during apoptosis.

Vaishnav M, MacFarlane M, Dickens M.
Exp Cell Res. 2011 Apr 15;317(7):1028-39. Epub 2011 Jan 13.

 

Book Chapter:

“p53 in the Clinics” Chapter contribution: “The p53 family and stem cell biology” (2011)
Agostini M, Rufini A, Bampton ETW, Bernassola F, Melino G, Knight RA

 

microRNA-34a regulates neurite outgrowth, spinal morphology, and function.

Agostini M, Tucci P, Steinert JR, Shalom-Feuerstein R, Rouleau M, Aberdam D, Forsythe ID, Young KW, Ventura A, Concepcion CP, Han YC, Candi E, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21099-104. Epub 2011 Dec 12.

 

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.

Agostini M, Tucci P, Killick R, Candi E, Sayan BS, Rivetti di Val Cervo P, Nicotera P, McKeon F, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):21093-8. Epub 2011 Dec 12.

 

Cell death pathology: The war against cancer.

Rufini A, Melino G.

Biochem Biophys Res Commun. 2011 Sep 28. [Epub ahead of print]

 

Cell death pathology: Perspective for human diseases.

Agostini M, Tucci P, Melino G.

Biochem Biophys Res Commun. 2011 Sep 21. [Epub ahead of print]

 

Cell death pathology: Cross-talk with autophagy and its clinical implications.

Amelio I, Melino G, Knight RA.

Biochem Biophys Res Commun. 2011 Oct 22;414(2):277-81. Epub 2011 Sep 22.

 

p63 in tooth development.

Rufini A, Barlattani A, Docimo R, Velletri T, Niklison-Chirou MV, Agostini M, Melino G.

Biochem Pharmacol. 2011 Nov 15;82(10):1256-61. Epub 2011 Jul 20.

 

p73 in Cancer.

Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, Niklison-Chirou MV, Conforti F, Velletri T, Mastino A, Mak TW, Melino G, Knight RA.

Genes Cancer. 2011 Apr;2(4):491-502.

 

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53.

Melino G.

Cell Death Differ. 2011 Sep;18(9):1487-99. doi: 10.1038/cdd.2011.81. Epub 2011 Jul 15.

 

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism.

Al-Bahlani S, Fraser M, Wong AY, Sayan BS, Bergeron R, Melino G, Tsang BK.

Oncogene. 2011 Oct 13;30(41):4219-30. doi: 10.1038/onc.2011.134. Epub 2011 Apr 25.

 

miR-146a is modulated in human endothelial cell with aging.

Vasa-Nicotera M, Chen H, Tucci P, Yang AL, Saintigny G, Menghini R, Mahè C, Agostini M, Knight RA, Melino G, Federici M.

Atherosclerosis. 2011 Aug;217(2):326-30. Epub 2011 Apr 5.

 

p73: a multifunctional protein in neurobiology.

Killick R, Niklison-Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, Velletri T, Tucci P, Sayan BS, Conforti F, Gallagher E, Nicotera P, Mak TW, Melino G, Knight RA, Agostini M.

Mol Neurobiol. 2011 Apr;43(2):139-46. Epub 2011 Mar 8. Review.

 

Ageing, neuronal connectivity and brain disorders: an unsolved ripple effect.

Bano D, Agostini M, Melino G, Nicotera P.

Mol Neurobiol. 2011 Apr;43(2):124-30. Epub 2011 Jan 15. Review.

 

Mitochondrial quality control and Parkinson’s disease: a pathway unfolds.

de Castro IP, Martins LM, Loh SH.

Mol Neurobiol. 2011 Apr;43(2):80-6. Epub 2010 Dec 1. Review.

 

PINK1 cleavage at position A103 by the mitochondrial protease PARL.

Deas E, Plun-Favreau H, Gandhi S, Desmond H, Kjaer S, Loh SH, Renton AE, Harvey RJ, Whitworth AJ, Martins LM, Abramov AY, Wood NW.

Hum Mol Genet. 2011 Mar 1;20(5):867-79. Epub 2010 Dec 6.

 

The regulatory role of heme in neurons.

Smith AG, Raven EL, Chernova T.

Metallomics. 2011 Oct 4;3(10):955-62. Epub 2011 Sep 16.

 

Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons.

Chernova T, Steinert JR, Richards P, Mistry R, Challiss RA, Jukes-Jones R, Cain K, Smith AG, Forsythe ID.

Mol Pharmacol. 2011 May;79(5):844-54. Epub 2011 Feb 15.

 

An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.

Johnson LA, Byrne HM, Willis AE, Laughton CA.

Integr Biol (Camb). 2011 Aug;3(8):843-9. Epub 2011 Jul 19.

 

The biological and therapeutic relevance of mRNA translation in cancer.

Blagden SP, Willis AE.

Nat Rev Clin Oncol. 2011 May;8(5):280-91. Epub 2011 Mar 1. Review.

 

ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53.

Roobol A, Roobol J, Carden MJ, Bastide A, Willis AE, Dunn WB, Goodacre R, Smales CM.

Biochem J. 2011 Apr 15;435(2):499-508.

 

 

2010 Publications

 

 

The involvement of microRNAs in Type 2 diabetes.

Ferland-McCollough D, Ozanne SE, Siddle K, Willis AE, Bushell M.

Biochem Soc Trans. 2010 Dec;38(6):1565-70. Review.

 

Translational regulation of gene expression during conditions of cell stress.

Spriggs KA, Bushell M, Willis AE.

Mol Cell. 2010 Oct 22;40(2):228-37. Review.

 

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. Epub 2010 Mar 8.

 

Regulation of Myc by miR-34c: A mechanism to prevent genomic instability?

Cannell IG, Bushell M.

Cell Cycle. 2010 Jul 15;9(14):2726-30. Epub 2010 Jul 27. Review.

 

Inhibition of hypoxia-inducible factor-1alpha (HIF-1alpha) protein synthesis by DNA damage inducing agents.

Lou JJ, Chua YL, Chew EH, Gao J, Bushell M, Hagen T.

PLoS One. 2010 May 7;5(5):e10522.

 

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12499-504. Epub 2010 Jun 28.

 

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.

Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.

Oncogene. 2010 May 13;29(19):2884-91. Epub 2010 Mar 1.

 

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

 

Proteomic analysis of B-cell malignancies.

Boyd RS, Dyer MJ, Cain K.

J Proteomics. 2010 Sep 10;73(10):1804-22. Epub 2010 Mar 24. Review.

 

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

 

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.

Hum Mol Genet. 2010 May 1;19(9):1669-77. Epub 2010 Feb 1.


TRAIL-Induced Apoptosis Is Preferentially Mediated via TRAIL Receptor 1 in Pancreatic Carcinoma Cells and Profoundly Enhanced by XIAP Inhibitors
Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Moller P, Zwacka RM, Debatin KM, Fulda S
Clin Cancer Res 16(23):5734-5749 01 Dec 2010

 

The in vitro cleavage of the hAtg proteins by cell death proteases.

Norman JM, Cohen GM, Bampton ET.

Autophagy. 2010 Nov;6(8):1042-56.

 

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM.

Clin Cancer Res. 2010 Aug 15;16(16):4217-25. Epub 2010 Jul 2.

 

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. Epub 2010 Apr 7.

 

Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse.

Haustein MD, Read DJ, Steinert JR, Pilati N, Dinsdale D, Forsythe ID.

J Physiol. 2010 Dec 1;588(Pt 23):4683-93. Epub 2010 Oct 11.

 

Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons.

Young KW, Piñon LG, Bampton ET, Nicotera P.

J Biochem Mol Toxicol. 2010 Sep-Oct;24(5):335-41.

 

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. Epub 2010 Apr 7.

 

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

 

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.

Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.

Hum Mol Genet. 2010 May 1;19(9):1669-77. Epub 2010 Feb 1.

 

Alteration of the nuclear pore complex in Ca(2+)-mediated cell death.

Bano D, Dinsdale D, Cabrera-Socorro A, Maida S, Lambacher N, McColl B, Ferrando-May E, Hengartner MO, Nicotera P.

Cell Death Differ. 2010 Jan;17(1):119-33. Epub.

 

Splenic infarction associated with rapidly progressive chronic lymphocytic leukemia with complex karyotype and ATM mutation.

Dyer MJ, Majid A, Walewska R, Gesk S, Harder L, Siebert R, Morgan B.

Leuk Res. 2011 May;35(5):e55-7. Epub 2010 Dec 24. No abstract available.

 

CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL.

Majid A, Lin TT, Best G, Fishlock K, Hewamana S, Pratt G, Yallop D, Buggins AG, Wagner S, Kennedy BJ, Miall F, Hills R, Devereux S, Oscier DG, Dyer MJ, Fegan C, Pepper C.

Leuk Res. 2011 Jun;35(6):750-6. Epub 2010 Nov 18.

 

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood.

Vogler M, Furdas SD, Jung M, Kuwana T, Dyer MJ, Cohen GM.

Clin Cancer Res. 2010 Aug 15;16(16):4217-25. Epub 2010 Jul 2.

 

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies.

Nagel I, Szczepanowski M, Martín-Subero JI, Harder L, Akasaka T, Ammerpohl O, Callet-Bauchu E, Gascoyne RD, Gesk S, Horsman D, Klapper W, Majid A, Martinez-Climent JA, Stilgenbauer S, Tönnies H, Dyer MJ, Siebert R.

Blood. 2010 Aug 26;116(8):1317-20. Epub 2010 May 11.

 

Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol.

Cario G, Zimmermann M, Romey R, Gesk S, Vater I, Harbott J, Schrauder A, Moericke A, Izraeli S, Akasaka T, Dyer MJ, Siebert R, Schrappe M, Stanulla M.

Blood. 2010 Jul 1;115(26):5393-7. Epub 2010 Apr 8.

 

Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.

Baou M, Kohlhaas SL, Butterworth M, Vogler M, Dinsdale D, Walewska R, Majid A, Eldering E, Dyer MJ, Cohen GM.

Haematologica. 2010 Sep;95(9):1510-8. Epub 2010 Apr 7.

 

Proteomic analysis of B-cell malignancies.

Boyd RS, Dyer MJ, Cain K.

J Proteomics. 2010 Sep 10;73(10):1804-22. Epub 2010 Mar 24. Review.

 

HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species.

Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.

Nat Immunol. 2010 Mar;11(3):265-72. Epub 2010 Feb 7.

 

Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?

Dyer MJ, Akasaka T, Capasso M, Dusanjh P, Lee YF, Karran EL, Nagel I, Vater I, Cario G, Siebert R.

Blood. 2010 Feb 25;115(8):1490-9. Epub 2009 Dec 30. Review.

 

Identification of Thr29 as a critical phosphorylation site that activates the human proton channel Hvcn1 in leukocytes.

Musset B, Capasso M, Cherny VV, Morgan D, Bhamrah M, Dyer MJ, DeCoursey TE.

J Biol Chem. 2010 Feb 19;285(8):5117-21. Epub 2009 Dec 26.

 

Acute hyperbilirubinaemia induces presynaptic neurodegeneration at a central glutamatergic synapse.

Haustein MD, Read DJ, Steinert JR, Pilati N, Dinsdale D, Forsythe ID.

J Physiol. 2010 Dec 1;588(Pt 23):4683-93. Epub 2010 Oct 11.

 

Nitric oxide signaling in brain function, dysfunction, and dementia.

Steinert JR, Chernova T, Forsythe ID.

Neuroscientist. 2010 Aug;16(4):435-52. Review.

 

Lateral olivocochlear (LOC) neurons of the mouse LSO receive excitatory and inhibitory synaptic inputs with slower kinetics than LSO principal neurons.

Sterenborg JC, Pilati N, Sheridan CJ, Uchitel OD, Forsythe ID, Barnes-Davies M.

Hear Res. 2010 Dec 1;270(1-2):119-26. Epub 2010 Sep 8.

 

An introduction to Peter Stanfield’s festschrift.

Forsythe ID, Grubb BD, Dale N.

J Physiol. 2010 Sep 1;588(Pt 17):3139-40. No abstract available.

 

Presynaptic and postsynaptic origin of multicomponent extracellular waveforms at the endbulb of Held-spherical bushy cell synapse.

Typlt M, Haustein MD, Dietz B, Steinert JR, Witte M, Englitz B, Milenkovic I, Kopp-Scheinpflug C, Forsythe ID, Rübsamen R.

Eur J Neurosci. 2010 May;31(9):1574-81.

 

Going native: voltage-gated potassium channels controlling neuronal excitability.

Johnston J, Forsythe ID, Kopp-Scheinpflug C.

J Physiol. 2010 Sep 1;588(Pt 17):3187-200. Epub 2010 Jun 2. Review.

 

Gain of function in FHM-1 Ca(V)2.1 knock-in mice is related to the shape of the action potential.

Inchauspe CG, Urbano FJ, Di Guilmi MN, Forsythe ID, Ferrari MD, van den Maagdenberg AM, Uchitel OD.

J Neurophysiol. 2010 Jul;104(1):291-9. Epub 2010 May 19.

 

Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.

McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut-Smith MP.

J Physiol. 2010 May 1;588(Pt 9):1399-406. Epub 2010 Mar 22.

 

Regulation of Kv channel expression and neuronal excitability in rat medial nucleus of the trapezoid body maintained in organotypic culture.

Tong H, Steinert JR, Robinson SW, Chernova T, Read DJ, Oliver DL, Forsythe ID.

J Physiol. 2010 May 1;588(Pt 9):1451-68. Epub 2010 Mar 8.

 

NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstem in vitro.

Steinert JR, Postlethwaite M, Jordan MD, Chernova T, Robinson SW, Forsythe ID.

J Physiol. 2010 Feb 1;588(Pt 3):447-63. Epub 2009 Dec 14.

 

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.

Kannan M, Steinert JR, Forsythe ID, Smith AG, Chernova T.

Neurobiol Aging. 2010 Sep;31(9):1543-53. Epub 2008 Oct 31.

 

Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.

Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang SD, Parry JD, Lyon JJ, Marczylo EL, Gant TW.

PLoS One. 2010 Sep 15;5(9):e12733.

 

Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability.

Foster CT, Dovey OM, Lezina L, Luo JL, Gant TW, Barlev N, Bradley A, Cowley SM.

Mol Cell Biol. 2010 Oct;30(20):4851-63. Epub 2010 Aug 16.

 

Upregulation of nuclear-encoded mitochondrial LON protease in HAART-treated HIV-positive patients with lipodystrophy: implications for the pathogenesis of the disease.

Pinti M, Gibellini L, Guaraldi G, Orlando G, Gant TW, Morselli E, Nasi M, Salomoni P, Mussini C, Cossarizza A.

AIDS. 2010 Mar 27;24(6):841-50.

 

Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.

Ridd K, Dhir S, Smith AG, Gant TW.

Toxicol In Vitro. 2010 Apr;24(3):910-5. Epub 2009 Nov 27.

 

Application of connectivity mapping in predictive toxicology based on gene-expression similarity.

Smalley JL, Gant TW, Zhang SD.

Toxicology. 2010 Feb 9;268(3):143-6. Epub 2009 Sep 27. Review.

 

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors.

Stadel D, Mohr A, Ref C, MacFarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Möller P, Zwacka RM, Debatin KM, Fulda S.

Clin Cancer Res. 2010 Dec 1;16(23):5734-49. Epub 2010 Oct 12.

 

TRAIL-induced apoptosis is preferentially mediated via TRAIL receptor 1 in pancreatic carcinoma cells and profoundly enhanced by XIAP inhibitors

Stadel D, Macfarlane M, Zhou S, Humphreys R, Bachem M, Cohen G, Moeller P, Debatin KM, Fulda S

ONKOLOGIE Volume: 33 Supplement: 6 Pages: 24-24 Published: OCT 2010

 

Development of a doxycyclinedependent caspase 3 death switch model to assess the immune response to rapid and synchronous tumour cell apoptosis in vivo

Melis M, Simpson K, Honeychurch J, Weldman A, MacFarlane M, Dive C, Illidge T

EJC SUPPLEMENTS Volume: 8 Issue: 5 Pages: 101-102 Meeting Abstract: 397 Published: JUN 2010

 

Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.

Young KW, Piñón LG, Dhiraj D, Twiddy D, Macfarlane M, Hickman J, Nicotera P.

Neuropharmacology. 2010 Jun;58(8):1258-67. Epub 2010 Mar 20.

 

A TRAIL-R1-specific ligand in combination with doxorubicin selectively targets primary breast tumour cells for apoptosis

Twiddy D, Naik S, Mistry R, Edwards J, Walker RA, Cohen GM, MacFarlane M

BREAST CANCER RESEARCH Volume: 12 Supplement: 1 Pages: S17-S18 Article Number: P58

Published 18 May 2010

 

Book Chapter:
MacFarlane M (2010) ‘Death Receptors at the Molecular Level: Therapeutic Implications’ In: Encyclopedia of Life Sciences. John Wiley & Sons Ltd, Chichester. http://www.els.net

 

Dysfunction and recovery of synapses in prion disease: implications for neurodegeneration.

Moreno JA, Mallucci GR.

Biochem Soc Trans. 2010 Apr;38(2):482-7. Review.

 

The role of GPI-anchored PrP C in mediating the neurotoxic effect of scrapie prions in neurons.

Radford HE, Mallucci GR.

Curr Issues Mol Biol. 2010;12(2):119-27. Epub 2009 Sep 18. Review.

 

Drosophila happyhour modulates JNK-dependent apoptosis.

Lam D, Shah S, de Castro IP, Loh SH, Martins LM.

Cell Death Dis. 2010 Aug 19;1:e66.

 

Cancer and neurodegeneration: between the devil and the deep blue sea.

Plun-Favreau H, Lewis PA, Hardy J, Martins LM, Wood NW.

PLoS Genet. 2010 Dec 23;6(12):e1001257. Review.

 

Mitochondrial quality control and neurological disease: an emerging connection.

de Castro IP, Martins LM, Tufi R.

Expert Rev Mol Med. 2010 Apr 19;12:e12. Review.

 

Policy and procedures on scientific misconduct.

Melino G.

Cell Death Differ. 2010 Dec;17(12):1805-6. No abstract available.

 

p73 regulates maintenance of neural stem cell.

Agostini M, Tucci P, Chen H, Knight RA, Bano D, Nicotera P, McKeon F, Melino G.

Biochem Biophys Res Commun. 2010 Dec 3;403(1):13-7. Epub 2010 Oct 25.

 

Skn-1a/Oct-11 and ΔNp63α exert antagonizing effects on human keratin expression.

Lena AM, Cipollone R, Amelio I, Catani MV, Ramadan S, Browne G, Melino G, Candi E.

Biochem Biophys Res Commun. 2010 Oct 29;401(4):568-73. Epub 2010 Oct 1.

 

Journal club. A cancer biologist weighs up p53, metabolism and cancer.

Melino G.

Nature. 2010 Aug 19;466(7309):905. No abstract available.

 

Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.

Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, Browne GJ, Agostini M, Bernardini S, Knight RA, Mak TW, Melino G.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12877-82. Epub 2010 Jul 6.

 

p73 and p63 regulate the expression of fibroblast growth factor receptor 3.

Sayan AE, D’Angelo B, Sayan BS, Tucci P, Cimini A, Cerù MP, Knight RA, Melino G.

Biochem Biophys Res Commun. 2010 Apr 9;394(3):824-8. Epub 2010 Mar 16.

 

miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro.

Chen H, Shalom-Feuerstein R, Riley J, Zhang SD, Tucci P, Agostini M, Aberdam D, Knight RA, Genchi G, Nicotera P, Melino G, Vasa-Nicotera M.

Biochem Biophys Res Commun. 2010 Apr 16;394(4):921-7. Epub 2010 Mar 15.

 

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.

Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW.

Genes Dev. 2010 Mar 15;24(6):549-60. Epub 2010 Mar 1.

 

Induction of TAp63 by histone deacetylase inhibitors.

Sayan BS, Yang AL, Conforti F, Bernardini S, Tucci P, Vasa-Nicotera M, Knight RA, Melino G.

Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. Epub 2009 Dec 30.

 

Complex gene-chemical interactions: hepatic uroporphyria as a paradigm.

Smith AG, Elder GH.

Chem Res Toxicol. 2010 Apr 19;23(4):712-23. Review.

 

Defective TPA signalling compromises HaCat cells as a human in vitro skin carcinogenesis model.

Ridd K, Dhir S, Smith AG, Gant TW.

Toxicol In Vitro. 2010 Apr;24(3):910-5. Epub 2009 Nov 27.

 

Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.

Kannan M, Steinert JR, Forsythe ID, Smith AG, Chernova T.

Neurobiol Aging. 2010 Sep;31(9):1543-53. Epub 2008 Oct 31.

 

Translation deregulation in B-cell lymphomas.

Horvilleur E, Wilson LA, Willis AE.

Biochem Soc Trans. 2010 Dec;38(6):1593-7.

 

The role of IRES trans-acting factors in regulating translation initiation.

King HA, Cobbold LC, Willis AE.

Biochem Soc Trans. 2010 Dec;38(6):1581-6.

 

eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer’s disease.

Bottley A, Phillips NM, Webb TE, Willis AE, Spriggs KA.

PLoS One. 2010 Sep 28;5(9). pii: e13030.

 

The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.

Burrows C, Abd Latip N, Lam SJ, Carpenter L, Sawicka K, Tzolovsky G, Gabra H, Bushell M, Glover DM, Willis AE, Blagden SP.

Nucleic Acids Res. 2010 Sep;38(16):5542-53. Epub 2010 Apr 29.

 

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.

Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.

Oncogene. 2010 May 13;29(19):2884-91. Epub 2010 Mar 1.

 

Dysregulation of protein synthesis and disease.

Le Quesne JP, Spriggs KA, Bushell M, Willis AE.

J Pathol. 2010 Jan;220(2):140-51. Review.

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