Recent Publications

2017

Till stress do us ataRT: a novel toxin-antitoxin system targeting translation initiation.
Pizzinga M, Harvey RF, Willis AE.
Cell Death Differ. 2017 Jun;24(6):951-952. doi: 10.1038/cdd.2017.66.

RTN3 Is a Novel Cold-Induced Protein and Mediates Neuroprotective Effects of RBM3.
Bastide A, Peretti D, Knight JR, Grosso S, Spriggs RV, Pichon X, Sbarrato T, Roobol A, Roobol J, Vito D, Bushell M, von der Haar T, Smales CM, Mallucci GR, Willis AE.
Curr Biol. 2017 Mar 6;27(5):638-650. doi: 10.1016/j.cub.2017.01.047

Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.
Falletta P, Sanchez-Del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, Lu X, Tüting T, Middleton M, Buffa FM, Willis AE, Pavitt G, Ronai ZA, Sauka-Spengler T, Hölzel M, Goding CR.
Genes Dev. 2017 Jan 1;31(1):18-33. doi: 10.1101/gad.290940.116.

2016

Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer.
Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P.
J Exp Med. 2016 Oct 17;213(11):2503-2523.

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Soukarieh F, Nowicki MW, Bastide A, Pöyry T, Jones C, Dudek K, Patwardhan G, Meullenet F, Oldham NJ, Walkinshaw MD, Willis AE, Fischer PM.
Eur J Med Chem. 2016 Nov 29;124:200-217. doi: 10.1016/j.ejmech.2016.08.047.

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia cells.
Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Hidalgo MS, Leonard E, Willis AE, Forconi F, Stevenson FK, Steele AJ, Coldwell MJ, Packham G.
Oncotarget. 2016 Nov 15;7(46):74807-74819. doi: 10.18632/oncotarget.11655.

A ribosome-related signature in peripheral blood CLL B cells is linked to reduced survival following treatment.
Sbarrato T, Horvilleur E, Pöyry T, Hill K, Chaplin LC, Spriggs RV, Stoneley M, Wilson L, Jayne S, Vulliamy T, Beck D, Dokal I, Dyer MJ, Yeomans AM, Packham G, Bushell M, Wagner SD, Willis AE.
Cell Death Dis. 2016 Jun 2;7(6):e2249. doi: 10.1038/cddis.2016.148.

Translational Control: Selective Upregulation of ECM Components Drives Tumour Growth.
Willis AE.
Curr Biol. 2016 Mar 21;26(6):R241-3. doi: 10.1016/j.cub.2016.01.053.

Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease.
Chernova T, Sun XM, Powley IR, Galavotti S, Grosso S, Murphy FA, Miles GJ, Cresswell L, Antonov AV, Bennett J, Nakas A, Dinsdale D, Cain K, Bushell M, Willis AE, MacFarlane M.
Cell Death Differ. 2016 Feb 19. doi: 10.1038/cdd.2015.165.

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
Knight JR, Bastide A, Peretti D, Roobol A, Roobol J, Mallucci GR, Smales CM, Willis AE.
RNA 2016 Feb 8.

Temporal Regulation of Distinct Internal Ribosome Entry Sites of the Dicistroviridae Cricket Paralysis Virus.
Khong A, Bonderoff JM, Spriggs RV, Tammpere E, Kerr CH, Jackson TJ, Willis AE, Jan E.
Viruses 2016 Jan 19;8(1). pii: E25. doi: 10.3390/v8010025.

2015

Cap-Independent Translation in Hematological Malignancies.
Horvilleur E, Wilson LA, Bastide A, Piñeiro D, Pöyry TA, Willis AE.
Front Oncol 2015 Dec 21;5:293. doi: 10.3389/fonc.2015.00293.

Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation.
Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Sanchez Hidalgo M, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ, Packham G.
Blood. 2015 Oct 21. pii: blood-2015-07-660969.

A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JR, Puget S, Grill J, Grundy RG, Bushell M, Willis AE.
Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115.

Control of translation in the cold: implications for therapeutic hypothermia.
Knight JR, Willis AE.
Biochem Soc Trans. 2015 Jun;43(3):333-7. doi: 10.1042/BST20150052.

eIF4A1 is a promising new therapeutic target in ER-negative breast cancer.
Stoneley M, Willis AE.
Cell Death Differ. 2015 Apr;22(4):524-5. doi: 10.1038/cdd.2014.210.

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Peretti D, Bastide A, Radford H, Verity N, Molloy C, Martin MG, Moreno JA, Steinert JR, Smith T, Dinsdale D, Willis AE, Mallucci GR.
Nature 2015 Feb 12;518(7538):236-9. doi: 10.1038/nature14142.

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.
Knight JR, Bastide A, Roobol A, Roobol J, Jackson TJ, Utami W, Barrett DA, Smales CM, Willis AE.
Biochem J. 2015 Jan 15;465(2):227-38. doi: 10.1042/BJ20141014.

p58IPK is an inhibitor of the eIF2a kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM.
Biochem J. 2015 Jan 15;465(2):213-25. doi: 10.1042/BJ20140852.

2014

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression.
Mura M, Hopkins TG, Michael T, Abd-Latip N, Weir J, Aboagye E, Mauri F, Jameson C, Sturge J, Gabra H, Bushell M, Willis AE, Curry E, Blagden SP.
Oncogene. 2014 Dec 22. doi: 10.1038/onc.2014.428. [Epub ahead of print]

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, Pende M, Ryazanov AG, Sonenberg N, Meyuhas O, Hall MN, Bushell M, Willis AE, Sansom OJ.
Nature. 2014 Nov 5. doi: 10.1038/nature13896. [Epub ahead of print]

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.
Knight JR, Bastide A, Roobol A, Roobol J, Jackson TJ, Utami W, Barrett DA, Smales CM, Willis AE.
Biochem J. 2014 Oct 29. [Epub ahead of print]

p58(IPK) is an Inhibitor of the eIF2a Kinase GCN2 and its Localisation and Expression Underpin Protein Synthesis and ER Processing Capacity.
Roobol A, Roobol J, Bastide A, Knight JR, Willis AE, Smales CM.
Biochem J. 2014 Oct 20. [Epub ahead of print]

Evaluating bias-reducing protocols for RNA sequencing library preparation.
Jackson TJ, Spriggs RV, Burgoyne NJ, Jones C, Willis AE.
BMC Genomics. 2014 Jul 7;15:569. doi: 10.1186/1471-2164-15-569.

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.
Horvilleur E, Sbarrato T, Hill K, Spriggs RV, Screen M, Goodrem PJ, Sawicka K, Chaplin LC, Touriol C, Packham G, Potter KN, Dirnhofer S, Tzankov A, Dyer MJ, Bushell M, MacFarlane M, Willis AE.
Leukemia. 2014 May;28(5):1092-102. doi: 10.1038/leu.2013.295. Epub 2013 Oct 18.

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER.
Hall BS, Hill K, McKenna M, Ogbechi J, High S, Willis AE, Simmonds RE.
PLoS Pathog. 2014 Apr 3;10(4):e1004061. doi: 10.1371/journal.ppat.1004061. eCollection 2014 Apr.

The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3: b, i and h.
Roobol A, Roobol J, Carden MJ, Smith ME, Hershey JW, Bastide A, Knight JR, Willis AE, Smales CM.
Biochem J. 2014 Mar 1;458(2):213-24. doi: 10.1042/BJ20130979.

Large scale integration of drug-target information reveals poly-pharmacological drug action mechanisms in tumor cell line growth inhibition assays.
Knight RA, Gostev M, Ilisavskii S, Willis AE, Melino G, Antonov AV.
Oncotarget. 2014 Feb 15;5(3):659-66.

DRUGSURV: a resource for repositioning of approved and experimental drugs in oncology based on patient survival information.
Amelio I, Gostev M, Knight RA, Willis AE, Melino G, Antonov AV.
Cell Death Dis. 2014 Feb 6;5:e1051. doi: 10.1038/cddis.2014.9.

Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease.
Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, Willis AE, Mallucci GR, Loh SH, Martins LM.
Nat Cell Biol. 2014 Feb;16(2):157-66. doi: 10.1038/ncb2901. Epub 2014 Jan 19.

Remodelling of a polypyrimidine tract-binding protein complex during apoptosis activates cellular IRESs.
King HA, Cobbold LC, Pichon X, Pöyry T, Wilson LA, Booden H, Jukes-Jones R, Cain K, Lilley KS, Bushell M, Willis AE.
Cell Death Differ. 2014 Jan;21(1):161-71. doi: 10.1038/cdd.2013.135. Epub 2013 Oct 18.

2013

The chaperonin CCT interacts with and mediates the correct folding and activity of three subunits of translation initiation factor eIF3; 3b, 3i and 3h.
Roobol A, Roobol J, Carden MJ, Smith ME, Hershey JW, Bastide A, Knight JR, Willis AE, Smales CM.
Biochem J. 2013 Dec 10. [Epub ahead of print]

Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.
Moreno JA, Halliday M, Molloy C, Radford H, Verity N, Axten JM, Ortori CA, Willis AE, Fischer PM, Barrett DA, Mallucci GR.
Sci Transl Med. 2013 Oct 9;5(206):206ra138. doi: 10.1126/scitranslmed.3006767.

A role for eukaryotic initiation factor 4B overexpression in the pathogenesis of diffuse large B-cell lymphoma.
Horvilleur E, Sbarrato T, Hill K, Spriggs RV, Screen M, Goodrem PJ, Sawicka K, Chaplin LC, Touriol C, Packham G, Potter KN, Dirnhofer S, Tzankov A, Dyer MJ, Bushell M, Macfarlane M, Willis AE.
Leukemia. 2013 Oct 18. doi: 10.1038/leu.2013.295. [Epub ahead of print]

Metabolic profiling of human CD4+ cells following treatment with methotrexate and anti-TNF-a infliximab.
Chimenti MS, Tucci P, Candi E, Perricone R, Melino G, Willis AE.
Cell Cycle. 2013 Sep 15;12(18):3025-36. doi: 10.4161/cc.26067. Epub 2013 Aug 19.

Rapamycin regulates biochemical metabolites.
Tucci P, Porta G, Agostini M, Antonov A, Garabadgiu AV, Melino G, Willis AE.
Cell Cycle. 2013 Aug 1;12(15):2454-67. doi: 10.4161/cc.25450. Epub 2013 Jun 28.

A perspective on mammalian upstream open reading frame function.
Somers J, Pöyry T, Willis AE.
Int J Biochem Cell Biol. 2013 Aug;45(8):1690-700. doi: 10.1016/j.biocel.2013.04.020. Epub 2013 Apr 25.

Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.
Meijer HA, Kong YW, Lu WT, Wilczynska A, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M.
Science. 2013 Apr 5;340(6128):82-5. doi: 10.1126/science.1231197.

Active regulator of SIRT1 is required for ribosome biogenesis and function.
Knight JR, Willis AE, Milner J.
Nucleic Acids Res. 2013 Apr;41(7):4185-97. doi: 10.1093/nar/gkt129. Epub 2013 Mar 5.

Ribosomal protein S25 dependency reveals a common mechanism for diverse internal ribosome entry sites and ribosome shunting.
Hertz MI, Landry DM, Willis AE, Luo G, Thompson SR.
Mol Cell Biol. 2013 Mar;33(5):1016-26. doi: 10.1128/MCB.00879-12. Epub 2012 Dec 28.

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes.
Tucci P, Porta G, Agostini M, Dinsdale D, Iavicoli I, Cain K, Finazzi-Agró A, Melino G, Willis A.
Cell Death Dis. 2013 Mar 21;4:e549. doi: 10.1038/cddis.2013.76.

2012

Failure of translation of human adenovirus mRNA in murine cancer cells can be partially overcome by L4-100K expression in vitro and in vivo.
Young AM, Archibald KM, Tookman LA, Pool A, Dudek K, Jones C, Williams SL, Pirlo KJ, Willis AE, Lockley M, McNeish IA.
Mol Ther. 2012 Sep;20(9):1676-88. doi: 10.1038/mt.2012.116. Epub 2012 Jun 26.

Programming of adipose tissue miR-483-3p and GDF-3 expression by maternal diet in type 2 diabetes.
Ferland-McCollough D, Fernandez-Twinn DS, Cannell IG, David H, Warner M, Vaag AA, Bork-Jensen J, Brøns C, Gant TW, Willis AE, Siddle K, Bushell M, Ozanne SE.
Cell Death Differ. 2012 Jun;19(6):1003-12. doi: 10.1038/cdd.2011.183. Epub 2012 Jan 6.

Sustained translational repression by eIF2a-P mediates prion neurodegeneration.
Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR.
Nature. 2012 May 6;485(7399):507-11. doi: 10.1038/nature11058.

RNA binding protein/RNA element interactions and the control of translation.
Pichon X, Wilson LA, Stoneley M, Bastide A, King HA, Somers J, Willis AE.
Curr Protein Pept Sci. 2012 Jun;13(4):294-304.

2011

An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.
Johnson LA, Byrne HM, Willis AE, Laughton CA.
Integr Biol (Camb). 2011 Aug;3(8):843-9. Epub 2011 Jul 19.

The biological and therapeutic relevance of mRNA translation in cancer.
Blagden SP, Willis AE.
Nat Rev Clin Oncol. 2011 May;8(5):280-91. Epub 2011 Mar 1.

ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53.
Roobol A, Roobol J, Carden MJ, Bastide A, Willis AE, Dunn WB, Goodacre R, Smales CM.
Biochem J. 2011 Apr 15;435(2):499-508.

2010

Translation deregulation in B-cell lymphomas.
Horvilleur E, Wilson LA, Willis AE.
Biochem Soc Trans. 2010 Dec;38(6):1593-7.

The role of IRES trans-acting factors in regulating translation initiation.
King HA, Cobbold LC, Willis AE.
Biochem Soc Trans. 2010 Dec;38(6):1581-6.

The involvement of microRNAs in Type 2 diabetes.
Ferland-McCollough D, Ozanne SE, Siddle K, Willis AE, Bushell M.
Biochem Soc Trans. 2010 Dec;38(6):1565-70. Review.

Translational regulation of gene expression during conditions of cell stress.
Spriggs KA, Bushell M, Willis AE.
Mol Cell. 2010 Oct 22;40(2):228-37. Review.

eIF4A inhibition allows translational regulation of mRNAs encoding proteins involved in Alzheimer’s disease.
Bottley A, Phillips NM, Webb TE, Willis AE, Spriggs KA.
PLoS One. 2010 Sep 28;5(9). pii: e13030.

The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.
Burrows C, Abd Latip N, Lam SJ, Carpenter L, Sawicka K, Tzolovsky G, Gabra H, Bushell M, Glover DM, Willis AE, Blagden SP.
Nucleic Acids Res. 2010 Sep;38(16):5542-53. Epub 2010 Apr 29.

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.
Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.
Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. Epub 2010 Mar 8.

Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.
Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.
Oncogene. 2010 May 13;29(19):2884-91. Epub 2010 Mar 1.

Dysregulation of protein synthesis and disease.
Le Quesne JP, Spriggs KA, Bushell M, Willis AE.
J Pathol. 2010 Jan;220(2):140-51. Review.

2009

Co-ordinated regulation of translation following DNA damage.
Kondrashov AV, Spriggs KA, Bushell M, Willis AE.
Cell Cycle. 2009 Oct 1;8(19):3067-8. Epub 2009 Oct 8. No abstract available.

The human insulin receptor mRNA contains a functional internal ribosome entry segment.
Spriggs KA, Cobbold LC, Ridley SH, Coldwell M, Bottley A, Bushell M, Willis AE, Siddle K.
Nucleic Acids Res. 2009 Sep;37(17):5881-93. Epub 2009 Aug 4.

Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE.
Genes Dev. 2009 May 15;23(10):1207-20.

Canonical initiation factor requirements of the Myc family of internal ribosome entry segments.
Spriggs KA, Cobbold LC, Jopling CL, Cooper RE, Wilson LA, Stoneley M, Coldwell MJ, Poncet D, Shen YC, Morley SJ, Bushell M, Willis AE.
Mol Cell Biol. 2009 Mar;29(6):1565-74. Epub 2009 Jan 5.

Viral strategies to subvert the mammalian translation machinery.
Roberts LO, Jopling CL, Jackson RJ, Willis AE.
Prog Mol Biol Transl Sci. 2009;90:313-67. Epub 2009 Oct 27.

2008

Polypyrimidine-tract-binding protein: a multifunctional RNA-binding protein.
Sawicka K, Bushell M, Spriggs KA, Willis AE.
Biochem Soc Trans. 2008 Aug;36(Pt 4):641-7. Review.

The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene.
Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M.
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8866-71. Epub 2008 Jun 25.

SF2/ASF TORCs up translation.
Bushell M, Stoneley M, Spriggs KA, Willis AE.
Mol Cell. 2008 May 9;30(3):262-3.

A gastrin transcript expressed in gastrointestinal cancer cells contains an internal ribosome entry site.
Grabowska AM, Berry CA, Hughes J, Bushell M, Willis AE, Watson SA.
Br J Cancer. 2008 May 20;98(10):1696-703. Epub 2008 Apr 8.

Re-programming of translation following cell stress allows IRES-mediated translation to predominate.
Spriggs KA, Stoneley M, Bushell M, Willis AE.
Biol Cell. 2008 Jan;100(1):27-38. Review.

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.
Cobbold LC, Spriggs KA, Haines SJ, Dobbyn HC, Hayes C, de Moor CH, Lilley KS, Bushell M, Willis AE.
Mol Cell Biol. 2008 Jan;28(1):40-9. Epub 2007 Oct 29.

2007

A novel method for poly(A) fractionation reveals a large population of mRNAs with a short poly(A) tail in mammalian cells.
Meijer HA, Bushell M, Hill K, Gant TW, Willis AE, Jones P, de Moor CH.
Nucleic Acids Res. 2007;35(19):e132. Epub 2007 Oct 11.

Regulation of BAG-1 IRES-mediated translation following chemotoxic stress.
Dobbyn HC, Hill K, Hamilton TL, Spriggs KA, Pickering BM, Coldwell MJ, de Moor CH, Bushell M, Willis AE.
Oncogene. 2008 Feb 14;27(8):1167-74. Epub 2007 Aug 13.

Generation of DeltaTAp73 proteins by translation from a putative internal ribosome entry site.
Sayan AE, Roperch JP, Sayan BS, Rossi M, Pinkoski MJ, Knight RA, Willis AE, Melino G.
Ann N Y Acad Sci. 2007 Jan;1095:315-24.

2006

Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis.
Bushell M, Stoneley M, Kong YW, Hamilton TL, Spriggs KA, Dobbyn HC, Qin X, Sarnow P, Willis AE.
Mol Cell. 2006 Aug 4;23(3):401-12.

A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation.
Notari M, Neviani P, Santhanam R, Blaser BW, Chang JS, Galietta A, Willis AE, Roy DC, Caligiuri MA, Marcucci G, Perrotti D.
Blood. 2006 Mar 15;107(6):2507-16. Epub 2005 Nov 17.

2005

Investigation of interactions of polypyrimidine tract-binding protein with artificial internal ribosome entry segments.
Spriggs KA, Mitchell SA, Willis AE.
Biochem Soc Trans. 2005 Dec;33(Pt 6):1483-6. Review.

Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.
Mitchell SA, Spriggs KA, Bushell M, Evans JR, Stoneley M, Le Quesne JP, Spriggs RV, Willis AE.
Genes Dev. 2005 Jul 1;19(13):1556-71.

Internal ribosome entry segment-mediated translation during apoptosis: the role of IRES-trans-acting factors.
Spriggs KA, Bushell M, Mitchell SA, Willis AE.
Cell Death Differ. 2005 Jun;12(6):585-91. Review.

The implications of structured 5′ untranslated regions on translation and disease.
Pickering BM, Willis AE.
Semin Cell Dev Biol. 2005 Feb;16(1):39-47. Epub 2004 Dec 10. Review.

In this section

Willis Group