Dr. Rudi Prihandoko
Career Development Fellow
MRC Toxicology Unit
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK
My current project is aimed at investigating the role of GPR120, also known as free fatty acid receptor 4 in cancer progression and glucose metabolism. I will be focussing mainly on the role of phosphorylation in these biological processes. To enable these experiments, phosphorylation specific antibodies, knock-in mouse models and cell lines expressing the receptor will be developed. In addition, biochemical assays such as insulin secretion, angiogenesis and cell death assays will be set up to understand the mechanisms by which GPR120 activation influences glucose metabolism and cancer progression.
*Butcher AJ, *Prihandoko R, Kong KC, McWilliams P, Edwards JM, Bottrill A, Mistry S, Tobin AB. Differential G protein-coupled receptor phosphorylation provides evidence for a signaling bar code (2011). Journal of Biological Chemistry. 286(13):11506-18. *Joint first author.
Alvarez-Curto E, Prihandoko R, Tautermann CS, Zwier JM, Pediani JD, Lohse MJ, Hoffmann C, Tobin AB, Milligan G. Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL) (2011). Molecular Pharmacology. 80(6):1033-46.
Butcher AJ, Kong KC, Prihandoko R, Tobin AB. Physiological role of G protein coupled receptor phosphorylation (2012). Handbook of Experimental Pharmacology. 208:79-94.