Dr. Ivana Celardo
Career Development Fellow
MRC Toxicology Unit
LE1 9HN, UK
My previous studies were aimed at the understanding of molecular basis of cancer. I focused on the regulation of class I histone deacetelase 1 (HDAC1) and in particular on the biochemical aspects of its association with nucleosome NuRD corepressor complex. The understanding of the regulation of this corepressor complex is of particular relevance since HDAC1 is up-regulated in many cancers. I also pursued my interests in cancer biology by studying the involvement of the p53 family member, p63, in tumorigenesis. This led to the identification of novel downstream targets of p63, which mediate p63 tumor suppression function.
Currently I am interested on the involvement of mitochondrial dysfunction in neurodegenerative disorders, such as Parkinson’s disease (PD). Although most cases of PD are sporadic, several genes coding for mitochondria-associated proteins have been with with familial PD cases. The aim of my project is the study of these disease-associated genes, in order to highlight pathologic basis of PD. Drosophila melanogaster is my model of study, it has proven to be an excellent animal model for human neurodegenerative diseases.