Dr. L. Miguel Martins

Programme Leader

Headshot of Dr L. Miguel Martins

MRC Toxicology Unit
Hodgkin Building
Lancaster Road
Leicester
LE1 9HN, UK

Tel: +44 (0)116 252 5533
Email: lm795@mrc-tox.cam.ac.uk

Qualifications and Personal History

Unit Programme: Mitochondria and cell death regulation following toxic injury

Key words: mitochondria, Drosophila, bioinformatics, neurodegeneration, Parkinson’s disease

 

Investigator Biography

Miguel obtained his PhD in Molecular Medicine from the University of Porto, Portugal, while working at the Johns Hopkins School of Medicine (USA) and the University of Edinburgh (Scotland) on cell death mechanisms with Prof. William C. Earnshaw. He then moved to the Imperial Cancer Research Fund laboratories (now CRUK) to work on cellular signalling with Dr Julian Downward.  Miguel was appointed to his first independent position as a Programme Leader with the MRC Toxicology Unit in 2003.

Research Interests

The aim of Miguel’s research programme is understanding the cellular and molecular mechanisms that mitochondria use, as signaling hubs, for coping with toxic insults.  We aim to manipulate these signaling mechanisms to protect tissues such as heart, liver and the brain from toxicity following exposure and in disease conditions.  Thus, this is a cell biology-based programme that aims to provide detailed, applicable, mechanistic toxicology, to identify the molecular initiating events and downstream toxicity pathways, associated with loss of mitochondrial function, that are disease relevant.

 

Research Group

Dr Samantha Loh, Dr Juan Garrido-Maraver, Dr Ivana Celardo

Selected Publications

    Lehmann, S. et al. Folinic acid is neuroprotective in a fly model of Parkinson’s disease associated with pink1 mutations, matters (2017)

    Celardo, I. et al. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective, Cell Death and Differentiation (2017)

    Lehmann, S. et al. Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson’s disease. Biology Open (2016)

    Sood, P. et al. Paraquat-induced metabolic stress signature in human foetal mesencephalic cells. matters (2016)

    Celardo, I. et al. Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease, Cell Death and Disease (2016)

    Lehmann, S. et al. Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease. Cell Death and Disease (2016)

    Bartesaghi, S. et al. Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. PNAS (2015)

    Andree, M. et al. BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. The EMBO Journal (2014)

    Requejo-Aguilar, R. et al. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nature Communications 5, 1–9 (2014)

    Tufi, R. et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease. Nature Cell Biology  (2014)

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