Dr. Lia Panman
MRC Toxicology Unit
LE1 9HN, UK
Tel: +44 (0)116 252 5552
Qualifications and Personal History
Unit Programme: Neuronal model systems for examining toxicity
Key words: Embryonic stem cells, IPS cells, neuronal differentiation, development, dopamine neurons, differential vulnerability
Lia studied Molecular Biology at the University of Groningen (The Netherlands). She obtained her PhD from the University of Utrecht (The Netherlands) where she studied limb bud development with Professor Rolf Zeller. For her post-doc she went to the Karolinska Institute in Stockholm where she studied neuronal lineage specification during embryonic stem cell differentiation in the group of Professor Thomas Perlmann. She started her own research group at the MRC Toxicology Unit in Leicester in 2013. Her group has an interest in specification and function of dopaminergic neurons and uses embryonic stem (ES) cells to get mechanistic insight into vulnerability of dopaminergic neurons to toxic insults and the onset of Parkinson’s disease.
Neurons producing the neurotransmitter dopamine serve important brain functions and are implicated in disorders including Parkinson’s disease. This neuronal population is highly diverse consisting of several molecular and functional distinct subpopulations that innervate specific brain areas. Lia’s research team is focussed on understanding processes involved in dopamine neuron subtype diversification, function and target innervation. Her team is using ES cells to elucidate novel pathways involved in dopamine neuron subtype specification during mouse and human embryonic development. ES cell derived cultures enriched for substantia nigra dopaminergic neurons are used to model the selective vulnerability of dopaminergic neurons to toxic insults as observed in Parkinson’s disease. The ream is using system biology approaches to elucidate genes and pathways that mediate the cellular responses that trigger the selective degeneration of substantia nigra neurons upon toxic insults. Another research line in Lia’s team investigates the processes involved in establish dopaminergic connectivity using transgenic mouse models.
Dr Clement Soleilhavoup, Dr Pedro Garcao, Kieran Patrick (PhD student), Emma Moles-Garcia (PhD student), Debra Evens
Panman L*., Papathanou M., Laguna A., Oosterveen T., Volakakis N., Acampora D., Kurtsdotter I., Yoshitake T., Kehr J., Joodmardi E., Muhr J., Simeone A., Ericson J., Perlmann T*. (2014). Sox6 and Otx2 control the specification of substantia nigra and ventral tegmental area dopamine neurons. Cell reports 8(4), 1018-1025. *Corresponding author
Mong J*., Panman L*., Alekseenko Z., Kee N., Stanton LW, Ericson J. and Perlmann T. (2014). Transcription factor-induced lineage programming of noradrenaline and motor neurons from embryonic stem cells. Stem Cells 32(3), 609-622. *Joint first author
Panman L., Andersson E., Hedlund E., Kee N., Mong J., Uhde C., Deng Q., Alekseenko Z., Sandberg R., Stanton L.W., Ericson J., Perlmann T. (2011). Transcription factor-induced lineage selection of stem cell derived neural progenitor cells. Cell Stem Cell 8(6), 663-675
Panman L., Perlmann T. (2011). Tracing lineages to uncover neuronal identity. BMC Biology 9, 51
Deng Q., Andersson E., Hedlund E., Alekseenko Z., Panman L., Millonig J., Ericson J., Perlmann T. (2011). Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development 138, 3399-3408
Volakakis N., Kadkhodaei B., Joodmardi E., Wallis K., Panman L., Silvaggi J., Spiegelman B.M., Perlmann T. (2010). NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. PNAS 107(27), 12317-22