Dr. Lindsay Wilson
MRC Toxicology Unit
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK
Tel: +44 (0)116 252 5541
Qualifications and Personal History
2008-Present Postdoctoral Research Associate with the Anne Willis’ lab, funded by CRUK.
2008 Postdoctoral Research Associate studying the genetics of recombination in phage Lambda with Dr Gary J Sharples at Durham University.
2006-2007 Postdoctoral Research Associate studying mechanisms and evolution of competence in Haemophilus influenzae with Dr Rosemary Redfield at the University of British Columbia, Vancouver.
PhD The Enterobacterial Repeated Intergenic Consensus (ERIC) Sequence. Supervisors Professor Paul M Sharp and Dr Gary J Sharples at the University of Nottingham.
The Myc family of proteins are sequence-specific transcription factors that regulate target genes integral to processes of cell proliferation, differentiation and cell death. Expression of these proteins is tightly regulated, with deregulation associated with tumorigenesis.
The 5′ untranslated regions of some myc genes contain a complex RNA structural element called an internal ribosome entry segment (IRES). These, under the regulation of IRES trans-acting factors (ITAFs), facilitate a mechanism of translation initiation called internal ribosome entry. This can operate even when cap-dependent translation is compromised, for example to promote gene expression during apoptosis or genotoxic stress.
The Willis lab has recently identified a subset of ITAFs that interact specifically with Myc family IRESs. This current project aims to (1) identify patterns of Myc family ITAF expression and modification under different physiological conditions, (2) look for colocalisation of Myc family ITAFs with their cognate RNAs and (3) explore the role of these ITAFs in the cellular response to apoptosis and genotoxic stress.