Dr. Susann Lehmann

Career Development Fellow

Headshot of Dr Susann Lehmann

MRC Toxicology Unit
Hodgkin Building
PO Box 138
University of Leicester
Lancaster Road, Leicester

Email: sl410@le.ac.uk

Research Interests

I am interested in the mechanisms that maintain protein and mitochondrial homeostasis and how impairment in these responses manifests in disease such as neurodegeneration or cancer.

My previous work focussed on the regulation of protein homeostasis within muscle. Skeletal muscle is the largest protein reserve in the human body and excessive loss of muscle protein leads to reduced mobility and increased morbidity. Using a functional genomics approach, I identified kinases and phosphatases that are negative regulators of protein degradation by inhibiting known proteolytic systems. This work proposed potential targets for further study of muscle wasting.

My current project focuses on the mechanisms of mitochondrial quality control that maintain an efficient protein folding capacity within the organelle. Mitochondrial impairment due to mutations in genes part of the mitochondrial quality control has been associated with the development of neurodegenerative diseases such as Parkinson’s disease. Currently, I am specifically looking at mechanisms of metabolic adaption in response to impairment of mitochondrial quality control using two model organisms, C. elegans and D. melanogaster

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