Dr. Wei-ting Lu
MRC Toxicology Unit
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK
Tel: +44 (0)116 252 5590
Investigating the mechanism by which microRNAs repress translation.
Hall AE, Lu WT, Godfrey JD, Antonov AV, Paicu C, Moxon S, Dalmay T, Wilczynska A, Muller PA, Bushell M. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016 Apr 7;7:e2184. doi: 10.1038/cddis.2016.91
Lu WT, Bushell M. Old case, new leads: miRNA links Kaposi’s sarcoma-associated herpesvirus with sepsis. Cell Death Dis. 2014 Dec 4;5:e1560. doi: 10.1038/cddis.2014.516.
WT Lu, A Wilczynska, E Smith, M Bushell. The diverse roles of the eIF4A family: you are the company you keep. Biochem Soc Trans. 2014 Feb 1;42(1):166-72. doi: 10.1042/BST20130161.
A Kamenska, WT Lu, D Kubacka, H Broomhead, N Minshall, M Bushell, N Standart,. Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing Nucleic acids research, December 201, doi: 10.1093/nar/gkt1265
Meijer HA*, Kong YW*, Lu WT*, Wilczynska A*, Spriggs RV, Robinson SW, Godfrey JD, Willis AE, Bushell M. Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation. Science, 2013 5 April: Vol. 340 no. 6128 pp. 82-85 DOI: 10.1126/science.1231197
Lu WT, Lemonidis K, Drayton RM, Nouspikel T. The Fanconi anemia pathway is downregulated upon macrophage differentiation through two distinct mechanisms. Cell Cycle. 2011 Oct 1;10(19). [Epub ahead of print]
Hyka-Nouspikel N, Lemonidis K, Lu WT, Nouspikel T. Circulating human B lymphocytes are deficient in nucleotide excision repair and accumulate mutations upon proliferation. Blood. 2011 Jun 9;117(23):6277-86.