Professor Marion MacFarlane

Deputy Director and Programme Leader: Molecular Mechanisms of Cell Death

Headshot of Professor Marion MacFarlane

MRC Toxicology Unit
Hodgkin Building
Lancaster Road


Qualifications and Personal History

2004-Present Programme Leader, MRC Toxicology Unit
2011-Present Honorary Chair, Dept. of Biochemistry, University of Leicester
1998-2004 MRC Programme Leader-Track Scientist, MRC Toxicology Unit
1998-2004 MRC Visiting Research Fellow, Kimmel Cancer Centre, Philadelphia, USA
1992-1997 Senior Postdoctoral Research Fellow, MRC Toxicology Unit
1989-1992 Wellcome Trust Advanced Training Fellowship Award, University of Surrey
1989 PhD (University of Surrey) Biochemistry
1985 BSc Hons (University of Glasgow) Pharmacology

Selected Publications

    Twiddy D, Naik S, Mistry R, Edwards J, Walker RA, Cohen GM, MacFarlane M (2010) A TRAIL-R1-selective Ligand selectively targets Primary Breast Tumour cells for Apoptosis. Breast Cancer Res., 12 (Suppl 1): 16-19.

    Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M (2009) Reconstitution of the Death-inducing Signaling Complex (DISC) Reveals a Substrate Switch that Determines CD95-Mediated Death or Survival. Molecular Cell, 35:265-279.

    Dyer MJ, MacFarlane M, Cohen GM (2007) Barriers to effective TRAIL-targeted therapy of malignancy. J. Clin. Oncol., 25:4505-4506.

    Twiddy D, Cohen GM, MacFarlane M, Cain K (2006) Caspase-7 is directly activated by the approximately 700-kDa apoptosome complex and is released as a stable XIAP-caspase-7 approximately 200-kDa complex. J. Biol. Chem., 281:3876-3888.

    MacFarlane M, Kohlhaas SL, Sutcliffe MJ, Dyer MJ, and Cohen GM (2005). TRAIL Receptor-Selective Mutants Signal to Apoptosis via TRAIL-R1 in Primary Lymphoid Malignancies. Cancer Res., 65, 11265-11270.

    Sun X, Butterworth MB, MacFarlane M, Dubiel W, Ciechanover A, and Cohen GM (2004). Caspase activation inhibits proteasome function during apoptosis. Molecular Cell, 14, 81-93.

    Harper N, Hughes MA, Farrow SN, Cohen GM and MacFarlane M (2003). Protein kinase C modulates TRAIL-induced apoptosis by targeting the apical events of death receptor signalling. J. Biol. Chem., 278, 44338-44347.

    MacFarlane M, Merrison W, Bratton SB, and Cohen GM (2002). Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J. Biol. Chem., 277, 36611-6.

    Harper N, Farrow, SN, Kaptein A, Cohen GM, and MacFarlane M (2001). Modulation of TRAIL-induced NF-B activation by inhibition of apical caspases. J. Biol Chem., 276, 34743-34752.

    MacFarlane M, Merrison W, Dinsdale D, and Cohen GM (2000). Active caspases and cleaved cytokeratins are sequestered into cytoplasmic inclusions in TRAIL-induced apoptosis. J. Cell Biol., 148, 1239-1254.

    Chandler JM, Cohen GM, and MacFarlane M (1998). Different subcellular distribution of caspase-3 and caspase-7 following Fas-induced apoptosis in mouse liver.  J. Biol. Chem., 273, 10815-10818.

    MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, and Alnemri ES (1997). Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem., 272, 25417-25420.

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