Professor Anne Willis
Unit Director and Programme Leader
MRC Toxicology Unit
LE1 9HN, UK
Tel: +44 (0)116 252 5544 (Secretary)
Qualifications and Personal History
2010-Present Director, MRC Toxicology Unit
2008-2013 BBSRC Professorial Fellowship
2004-2010 Professor in Cancer Cell Biology, RNA Biology Group, University of Nottingham.
2000-2005 BBSRC Advanced Fellow.
2004 Professor in Biochemistry, University of Leicester.
2002-2004 Reader in Biochemistry, University of Leicester.
1992-2000 Lecturer in Biochemistry, University of Leicester.
1988-1992 Junior Research Fellow at Churchill College Cambridge & Research Associate in the Department of Biochemistry, University of Cambridge.
PhD ICRF (now CRUK) Clare Hall laboratories working with Dr T Lindahl.
Translational regulation of gene expression during conditions of cell stress.
Spriggs KA, Bushell M, Willis AE.
Mol Cell. 2010 Oct 22;40(2):228-37.
Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1.
Cobbold LC, Wilson LA, Sawicka K, King HA, Kondrashov AV, Spriggs KA, Bushell M, Willis AE.
Oncogene. 2010 May 13;29(19):2884-91.
Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE.
Genes Dev. 2009 May 15;23(10):1207-20.
Canonical initiation factor requirements of the Myc family of internal ribosome entry segments.
Spriggs KA, Cobbold LC, Jopling CL, Cooper RE, Wilson LA, Stoneley M, Coldwell MJ, Poncet D, Shen YC, Morley SJ, Bushell M, Willis AE.
Mol Cell Biol. 2009 Mar;29(6):1565-74.
Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.
Cobbold LC, Spriggs KA, Haines SJ, Dobbyn HC, Hayes C, de Moor CH, Lilley KS, Bushell M, Willis AE.
Mol Cell Biol. 2008 Jan;28(1):40-9.
Regulation of BAG-1 IRES-mediated translation following chemotoxic stress.
Dobbyn HC, Hill K, Hamilton TL, Spriggs KA, Pickering BM, Coldwell MJ, de Moor CH, Bushell M, Willis AE.
Oncogene. 2008 Feb 14;27(8):1167-74.
Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis.
Bushell M, Stoneley M, Kong YW, Hamilton TL, Spriggs KA, Dobbyn HC, Qin X, Sarnow P, Willis AE.
Mol Cell. 2006 Aug 4;23(3):401-12.
Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.
Mitchell SA, Spriggs KA, Bushell M, Evans JR, Stoneley M, Le Quesne JP, Spriggs RV, Willis AE.
Genes Dev. 2005 Jul 1;19(13):1556-71.
Bag-1 internal ribosome entry segment activity is promoted by structural changes mediated by poly(rC) binding protein 1 and recruitment of polypyrimidine tract binding protein 1.
Pickering BM, Mitchell SA, Spriggs KA, Stoneley M, Willis AE.
Mol Cell Biol. 2004 Jun;24(12):5595-605.
L-Myc protein synthesis is initiated by internal ribosome entry.
Jopling CL, Spriggs KA, Mitchell SA, Stoneley M, Willis AE.
RNA. 2004 Feb;10(2):287-98.
The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.
Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE.
Mol Cell. 2003 Mar;11(3):757-71.