Professor Gerald Cohen
Qualifications and Personal History
MRC Toxicology Unit, Deputy Director, 2000 – present
MRC Toxicology Unit, Acting Director, 1998 – 2000; 2009-2010.
MRC Toxicology Unit, Special Appointment, 1991 – 1998.
Honorary Professor of Biochemistry, University of Leicester, 1996 – present.
Reader in Toxicology and Head of Toxicology Unit, The School of Pharmacy, University of London, 1984 – 1991.
Visiting Research Fellow, Department of Toxicology, Karolinska Institute, Sweden, July-September 1988.
Senior Lecturer and Head of Toxicology Unit, School of Pharmacy, University of London, 1981 -1984.
Visiting Research Scientist, Oak Ridge, National Laboratory, Tennessee, U.S.A. April – September 1978.
Lecturer in Biochemical Pharmacology, University of Surrey, 1974 – 1980
My research has for many years been centred on understanding mechanisms of toxicity. My early research was focussed on chemical carcinogenesis and detailed mechanistic studies on lung metabolism and toxicity. I also studied in detail mechanisms of toxicity of quinones with particular emphasis on the relative importance of redox cycling and arylation. For the last ~ 20 years, my research has concentrated on understanding mechanisms of cell death, in particular apoptosis. We have made many seminal contributions to understanding basic mechanisms of apoptosis and some of our current studies are aimed at translating these findings to the clinic.
M. Vogler, S.D. Furdas, M. Jung, T. Kuwana, M.J.S. Dyer, and G.M. Cohen. Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT -263 due to albumin binding in blood. Clin. Cancer Res., 16, 4217-4225, 2010.
M. Baou, S.L. Kohlhaas, M. Butterworth, M. Vogler, D. Dinsdale, R. Walewska, A. Majid, E. Elderling, M J.S. Dyer, G. M. Cohen. Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells. Haematologica, 95, 1510-1518, 2010