Professor Giovanna Mallucci
MRC Toxicology Unit
PO Box 138
University of Leicester
Lancaster Road, Leicester
LE1 9HN, UK
Tel: +44 (0)116 252 5550 (/5029 lab)
Qualifications and Personal History
van Geest Professor of Clinical Neuroscience, University of Cambridge, 2014 –
ERC consolidator fellow 2015 – 2020
Honorary Consultant Neurologist, Addenbrookes Hospital, Cambridge 2013 –
Programme Leader, MRC Toxicology Unit 2008 –
Professor, Department of Cell Physiology and Pharmacology, University of Leicester 2008 – 2014
Frank May Medal for excellence in research and outstanding future promise, University of Leicester 2012
SciAm 50 Award: ‘Progress against Prions’; for leadership in research, 2007
Consultant Neurologist, National Hospital for Neurology and Neurosurgery 2005 – 2012
Fellow Royal College of Physicians (FRCP) 2012
Group Leader, MRC Prion Unit 2001-2008
Presidents Prize in Clinical Neuroscience, Royal Society of Medicine 2004
Queens Square prize in Neurology 2003
PhD (London) Neurogenetics, 2000
Training in Internal Medicine and Neurology, 1989-95
MBBS (MD) (London), 1988
BA (Oxon) Physiological Sciences, 1985
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity. Halliday M, Radford H, Sekine Y, Moreno JA, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D and Mallucci GR. Cell Death & Disease 2015 6:e1672. doi: 10.1038/cddis.2015.49.
RBM3 mediates structural plasticity and the protective effects of cooling in neurodegenerative disease. Peretti D, Bastide A, Verity N, Guerra Martin M, Molloy C, Moreno JA, Radford H, Steinert J, Dinsdale D, Willis AE and Mallucci GR. Nature 2015 518(7538):236-9. doi: 10.1038/nature14142
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease. Roberta Tufi, Sonia Gandhi, Inês P. de Castro, Susann Lehmann, Plamena R. Angelova, David Dinsdale, Emma Deas, Hélène Plun-Favreau, Pierluigi Nicotera, Andrey Y. Abramov, Anne E. Willis, Giovanna R. Mallucci, Samantha H. Y. Loh & L. Miguel Martins. Nature Cell Biology 2014 16,157–166
Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice. Julie A. Moreno, Mark Halliday, Colin Molloy, Helois Radford, Nicholas Verity, Jeffrey M. Axten, Catharine A. Ortori, Anne E. Willis, Peter M. Fischer, David A. Barrett and Giovanna R. Mallucci, Sci Transl Med 2013 Vol. 5, Issue 206, p. 206ra138
Sustained translational repression by eIF2α-P mediates prion neurodegeneration. Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Otori, David A. Barrett, Pavel Tsaytler, Anne Bertolotti, Anne E. Willis, Martin Bushell & Giovanna R. Mallucci. Nature 2012 May 6;485(7399):507-11
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease. White M, Farmer M, Mirabile I, Brandner S, Collinge J and Mallucci G. PNAS 2008, 32 10238-43
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Mallucci GR, Dickinson A, White M, Husna Khatun, Andrew D. Powell, Sebastian Brandner, John G. R. Jefferys and Collinge J. Neuron 2007 53, 323-335.
Depleting neuronal PrP during prion infection prevents disease and reverses spongiosis. Mallucci G, Dickinson A, Linehan J, Brandner S, Kloehn P and Collinge J. Science 2003 302, 871-4.
Post-natal PrP knockout alters hippocampal CA1 properties but does not result in neurodegeneration. Mallucci GR, Asante E, Ratte S, Linehan J, Gowland I, Jefferys J and Collinge J. EMBO J 2002 21, 202-10.
RBM3 mediates structural plasticity and the protective effects of cooling in neurodegenerative disease:
Neurodegenerative disease: RBM3, a protein upregulated during hibernation, provides new insights into neurodegeneration. Wood, H. Nature Reviews Neurology 11, 124 (2015) doi:10.1038/nrneurol.2015.9
Synaptic plasticity: Cold-shocked synapses. Carr, F. Nature Reviews Neuroscience 16, 124–125 (2015) doi:10.1038/nrn3922
Neurodegeneration: Cold shock protects the brain. Knott, G. Nature, 2015, 518(7538):177-8
Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice:
Putting the downstream breaks on neurodegeneration? Allan McCarthy, John McKinley and Tim Lynch MB. Movement disorders. Article first published online:27 DEC 2013 DOI: 10.1002/mds.25744
Neurodegenerative disease: Neurodegeneration halted with oral therapy in mice. Jones B. Nature Reviews Neurology. 9, 658 (december 2013) doi:10.1038/nrneurol.2013.226
A New PERKspective on Neurodegeneration. Wiep Scheper and Jeroen J. M. Hoozemans Science Translational Medicine 09 Oct 2013:Vol. 5, Issue 206, pp. 206fs37 DOI: 10.1126/scitranslmed.3007641
New methods of preventing neurodegeneration? lessons from prion diseases. Beaulieu-Boire I and Fox SH. Movement disorders.Article first published online: 17 DEC 2013 DOI: 10.1002/mds.25782
Sustained translational repression by eIF2α-P mediates prion neurodegeneration:
Lost in translation: Misfolded proteins may cause neurodegeneration by inhibiting normal protein production. Fox S. Movement disorders. Article first published online: 13 SEP 2012 DOI: 10.1002/mds.25130
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease:
Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Federoff H.J. and Mhyre T.R. Neuron 2007 53, 315-7.
Depleting neuronal PrP during prion infection prevents disease and reverses spongiosis:
In a First, Infected Mice Recover From Prion Disease. Jennifer Couzin Science 31 October 2003: Vol. 302 no. 5646 pp. 763-765 DOI: 10.1126/science.302.5646.763a
Modulating the unfolded protein response to prevent neurodegeneration and enhance memory. Halliday M, Mallucci GR. Neuropathol Appl Neurobiol. 2015 Jun;41(4):414-27. doi: 10.1111/nan.12211. PMID:25556298
Targeting the unfolded protein response in neurodegeneration: A new approach to therapy. Halliday M, Mallucci GR. Neuropharmacology. 2014 Jan;76 Pt A:169-74. doi: 10.1016/j.neuropharm. 2013.08.034. Epub 2013 Sep 10. PMID: 24035917
The Role of GPI-anchored PrPC in Mediating the Neurotoxic Effect of Scrapie Prions in Neurons. Helois E. Radford and Giovanna R. Mallucci. Curr. Issues Mol. Biol. (2010) 12: 119-128
pdf: The Role of GPI-anchored PrP(C) in Mediating the Neurotoxic Effect of Scrapie Prions in Neurons.
RNAi for the Treatment of Prion Disease: A Window for Intervention in Neurodegeneration?. White MD, Mallucci GR. CNS Neurol Disord Drug Targets. 2009 Nov;8(5):342-52 PubMed PMID: 19702576.
Therapy for prion diseases: Insights from the use of RNA interference. White MD, Mallucci GR. Prion. 2009 Jul-Sep;3(3):121-8. Epub 2009 Jul 16. PubMed PMID: 19597349.
Rational targeting for prion therapeutics. Mallucci G and Collinge J. Nature Reviews Neuroscience 2005 6, 23-34. doi:10.1038/nrn1584
Selected Press Links