Professor Kelvin Cain
Head of Science Facilities & Protein Profiling Group Leader
MRC Toxicology Unit
LE1 9HN, UK
Qualifications and Personal History
2013-Present Head of Science Facilities, MRC Toxicology Unit.
2011-Present Professorship, University of Leicester.
2002-Present Head of Protein Profiling Group, MRC Toxicology Unit.
1996-Present Band 2, Senior Scientist, MRC Toxicology Unit.
1977-1996 Tenured Scientist, MRC Toxicology Unit.
1976 PhD (Warwick University), Molecular Sciences.
1972 BSc Hons, Pharmacology.
Proteomic and biochemical characterisation of large protein complexes involved in cell death, mitochondrial proteomics and bioenergetics in malignant cells.
I have worked as a Research Scientist in the MRC Toxicology Unit for 39 years, largely working on apoptosis, cell death and cancer. I am now Head of Science Facilities at the MRC Toxicology Unit, in charge of the Proteomics, Genomics, Bioinformatics, EM and Advanced Light Imaging groups. I manage ten members of staff and co-supervise three PhD students. I have extensive experience in cell death, cellular metabolism, protein biochemistry, purification and enzymology. My own group, the Protein Profiling Group, has two full time members of staff and three joint PhD students and uses Proteomics and Mass Spectrometry to identify novel and aberrant proteins in cell death and cancer (see Research Interests). A major focus of our work is identifying and quantifying proteins involved in toxicity and cancer. These are mechanistic-based studies aimed at correlating signalling defects with changes in metabolism, and how these impact on cellular and organelle proteomes, which in turn modulate cell survival and cell death. Large protein complexes drive many of the key metabolic and biochemical pathways involved in cell death and survival; a major aim of our work is to characterise the proteomic stoichiometric composition of such complexes. Such information provides key understanding of how the complexes function and how this can be disrupted by potential toxic agents or tumorigenesis. These proteomic discovery studies are carried out in collaboration with Toxicology Unit programmes led by Professor Marion MacFarlane, Professor Anne Willis, Professor Martin Bushell, Dr Michal Malewicz and UoL researchers (e.g. Professor Martin Dyer). These studies have resulted in significant publications in high impact factor journals such as Molecular and Cellular Proteomics, Molecular Cell, Oncogene, Nature Immunology, Cell Death and Differentiation.
The summary of research interests provides a snapshot of the group’s research and illustrates how it interacts with other research groups in the Unit.
Powley IR, Hughes MA, Cain K, MacFarlane M.
Oncogene. 2016 Apr 25. doi: 10.1038/onc.2016.99.
Hughes MA, Powley IR, Jukes-Jones R, Horn S, Feoktistova M, Fairall L, Schwabe JW, Leverkus M, Cain K*, MacFarlane M.
Mol Cell. 2016 Mar 17;61(6):834-49. doi: 10.1016/j.molcel.2016.02.023.
Craxton A, Somers J, Munnur D, Jukes-Jones R, Cain K, Malewicz M.
Cell Death Differ. 2015 Jun;22(6):890-7. doi: 10.1038/cdd.2015.22.
King HA, Cobbold LC, Pichon X, Pöyry T, Wilson LA, Booden H, Jukes-Jones R, Cain K, Lilley KS, Bushell M, Willis AE.
Cell Death Differ. 2014 Jan;21(1):161-71. doi: 10.1038/cdd.2013.135.
Shliaha PV, Jukes-Jones R, Christoforou A, Fox J, Hughes C, Langridge J, Cain K, Lilley KS.
J Proteome Res. 2014 Jul 3;13(7):3360-9. doi: 10.1021/pr500220g.
Dickens LS, Boyd RS, Jukes-Jones R, Hughes MA, Robinson GL, Fairall L, Schwabe JW, Cain K*, Macfarlane M.
Mol Cell. 2012 Jul 27;47(2):291-305. doi: 10.1016/j.molcel.2012.05.004.
Robinson GL, Dinsdale D, Macfarlane M, Cain K*.
Oncogene. 2012 Nov 29;31(48):4996-5006. doi: 10.1038/onc.2012.13.
Feoktistova M1, Geserick P, Kellert B, Dimitrova DP, Langlais C, Hupe M, Cain K, MacFarlane M, Häcker G, Leverkus M.
Mol Cell. 2011 Aug 5;43(3):449-63. doi: 10.1016/j.molcel.2011.06.011.
Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P.
Mol Cell. 2011 Aug 5;43(3):432-48. doi: 10.1016/j.molcel.2011.06.006.
Boyd RS, Dyer MJ, Cain K.
J Proteomics. 2010 Sep 10;73(10):1804-22. doi: 10.1016/j.jprot.2010.03.010.
Capasso M, Bhamrah MK, Henley T, Boyd RS, Langlais C, Cain K, Dinsdale D, Pulford K, Khan M, Musset B, Cherny VV, Morgan D, Gascoyne RD, Vigorito E, DeCoursey TE, MacLennan IC, Dyer MJ.
Nat Immunol. 2010 Mar;11(3):265-72. doi: 10.1038/ni.1843.
Boyd RS, Jukes-Jones R, Walewska R, Brown D, Dyer MJ, Cain K.
Mol Cell Proteomics. 2009 Jul;8(7):1501-15. doi: 10.1074/mcp.M800515-MCP200.
Hughes MA, Harper N, Butterworth M, Cain K, Cohen GM, MacFarlane M.
Mol Cell. 2009 Aug 14;35(3):265-79. doi: 10.1016/j.molcel.2009.06.012.
Twiddy D, Cohen GM, Macfarlane M, Cain K*.
J Biol Chem. 2006 Feb 17;281(7):3876-88.
Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K*.
J Biol Chem. 2004 May 7;279(19):19665-82.
Cain K, Bratton SB, Cohen GM.
Biochimie. 2002 Feb-Mar;84(2-3):203-14.
* Joint corresponding author.